Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153161751> ?p ?o ?g. }
- W2153161751 endingPage "1203" @default.
- W2153161751 startingPage "1195" @default.
- W2153161751 abstract "To explore the relationship between responses to interferon (IFN) and the mutation patterns in the IFN sensitivity–determining region (ISDR; amino acid positions 2209–2248) in the NS5A gene of hepatitis C virus genotype 1b, a cohort of 334 patients was analyzed. The number of mutations in the ISDR was higher in patients with sustained response (SR) than in patients with transient or no response (P<.001). Patients with viruses mutated at positions 2209 (P=.02), 2216 (P=.01), or 2227 (P=.02) more frequently experienced SR than did those without these mutations. Mutation occurred most frequently at position 2218, where the presence of cysteine was significantly associated with SR. Thus, the mutation pattern in the ISDR affects the virologic response to IFN and reflects different influences on the function of the NS5A protein. ISDR sequence analysis would allow the prediction of clinical IFN efficacy in individual patients" @default.
- W2153161751 created "2016-06-24" @default.
- W2153161751 creator A5024762202 @default.
- W2153161751 creator A5033820162 @default.
- W2153161751 creator A5034220449 @default.
- W2153161751 creator A5045376146 @default.
- W2153161751 creator A5058386183 @default.
- W2153161751 creator A5066924600 @default.
- W2153161751 creator A5083289334 @default.
- W2153161751 date "2001-04-15" @default.
- W2153161751 modified "2023-10-12" @default.
- W2153161751 title "Number and Position of Mutations in the Interferon (IFN) Sensitivity–Determining Region of the Gene for Nonstructural Protein 5A Correlate with IFN Efficacy in Hepatitis C Virus Genotype 1b Infection" @default.
- W2153161751 cites W1968426124 @default.
- W2153161751 cites W1971792395 @default.
- W2153161751 cites W1975744467 @default.
- W2153161751 cites W1978883570 @default.
- W2153161751 cites W1985433337 @default.
- W2153161751 cites W1998238867 @default.
- W2153161751 cites W2012002512 @default.
- W2153161751 cites W2014165835 @default.
- W2153161751 cites W2015382649 @default.
- W2153161751 cites W2019943793 @default.
- W2153161751 cites W2027252289 @default.
- W2153161751 cites W2035566133 @default.
- W2153161751 cites W2037886185 @default.
- W2153161751 cites W2038987068 @default.
- W2153161751 cites W2039582463 @default.
- W2153161751 cites W2043585116 @default.
- W2153161751 cites W2046761147 @default.
- W2153161751 cites W2050776853 @default.
- W2153161751 cites W2052603653 @default.
- W2153161751 cites W2077662413 @default.
- W2153161751 cites W2079317094 @default.
- W2153161751 cites W2087347665 @default.
- W2153161751 cites W2088163099 @default.
- W2153161751 cites W2088820905 @default.
- W2153161751 cites W2091252834 @default.
- W2153161751 cites W2093043910 @default.
- W2153161751 cites W2109134539 @default.
- W2153161751 cites W2110815089 @default.
- W2153161751 cites W2122088474 @default.
- W2153161751 cites W2122151579 @default.
- W2153161751 cites W2122927258 @default.
- W2153161751 cites W2133929317 @default.
- W2153161751 cites W2134812217 @default.
- W2153161751 cites W2146883389 @default.
- W2153161751 cites W2148177756 @default.
- W2153161751 cites W2151440141 @default.
- W2153161751 cites W2152450239 @default.
- W2153161751 cites W2154168388 @default.
- W2153161751 cites W2158697492 @default.
- W2153161751 cites W2159954692 @default.
- W2153161751 cites W2160306227 @default.
- W2153161751 cites W2162234181 @default.
- W2153161751 cites W2170154427 @default.
- W2153161751 cites W2335845212 @default.
- W2153161751 cites W2341829866 @default.
- W2153161751 cites W2394827380 @default.
- W2153161751 cites W2397843321 @default.
- W2153161751 doi "https://doi.org/10.1086/319674" @default.
- W2153161751 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11262201" @default.
- W2153161751 hasPublicationYear "2001" @default.
- W2153161751 type Work @default.
- W2153161751 sameAs 2153161751 @default.
- W2153161751 citedByCount "62" @default.
- W2153161751 countsByYear W21531617512012 @default.
- W2153161751 countsByYear W21531617512013 @default.
- W2153161751 countsByYear W21531617512014 @default.
- W2153161751 countsByYear W21531617512015 @default.
- W2153161751 countsByYear W21531617512016 @default.
- W2153161751 crossrefType "journal-article" @default.
- W2153161751 hasAuthorship W2153161751A5024762202 @default.
- W2153161751 hasAuthorship W2153161751A5033820162 @default.
- W2153161751 hasAuthorship W2153161751A5034220449 @default.
- W2153161751 hasAuthorship W2153161751A5045376146 @default.
- W2153161751 hasAuthorship W2153161751A5058386183 @default.
- W2153161751 hasAuthorship W2153161751A5066924600 @default.
- W2153161751 hasAuthorship W2153161751A5083289334 @default.
- W2153161751 hasBestOaLocation W21531617511 @default.
- W2153161751 hasConcept C104317684 @default.
- W2153161751 hasConcept C135763542 @default.
- W2153161751 hasConcept C136449434 @default.
- W2153161751 hasConcept C159047783 @default.
- W2153161751 hasConcept C176944494 @default.
- W2153161751 hasConcept C2522874641 @default.
- W2153161751 hasConcept C2776178377 @default.
- W2153161751 hasConcept C2776408679 @default.
- W2153161751 hasConcept C2777103181 @default.
- W2153161751 hasConcept C2777668594 @default.
- W2153161751 hasConcept C2781463415 @default.
- W2153161751 hasConcept C501734568 @default.
- W2153161751 hasConcept C54355233 @default.
- W2153161751 hasConcept C86803240 @default.
- W2153161751 hasConcept C8891405 @default.
- W2153161751 hasConceptScore W2153161751C104317684 @default.
- W2153161751 hasConceptScore W2153161751C135763542 @default.
- W2153161751 hasConceptScore W2153161751C136449434 @default.
- W2153161751 hasConceptScore W2153161751C159047783 @default.