FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153175562> ?p ?o ?g. }

• W2153175562 endingPage "18" @default.
• W2153175562 startingPage "12" @default.
• W2153175562 abstract "RNA interference is an evolutionarily conserved process in which expression of a specific gene is post-transcriptionally inhibited by a small interfering RNA (siRNA), which recognizes a complementary mRNA and induces its degradation. Currently, RNA interference is being used extensively to inhibit expression of specific genes for experimental and therapeutic purposes. For applications in mammalian cells, siRNAs are designed to be <approximately 30 base pairs to avoid nonspecific effects that arise from inducing the cellular double-stranded RNA (dsRNA)-dependent protein kinase (PKR) response. Here we perform expression profiling in mammalian tissue-culture cells treated under standard conditions with conventional 21-bp siRNAs and find, unexpectedly, that >1000 genes involved in diverse cellular functions are nonspecifically stimulated or repressed. The effects on gene expression are dependent upon siRNA concentration and are stable throughout the course of siRNA treatment. Our results can be explained by previous studies showing that dsRNAs can affect multiple signaling and transcription pathways in addition to PKR. The potential for this widespread, nonspecific effect on mammalian gene expression must be carefully considered in the design of siRNA experiments and therapeutic applications." @default.
• W2153175562 created "2016-06-24" @default.
• W2153175562 creator A5006276626 @default.
• W2153175562 creator A5060605798 @default.
• W2153175562 creator A5075691104 @default.
• W2153175562 date "2003-12-17" @default.
• W2153175562 modified "2023-10-14" @default.
• W2153175562 title "Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs)" @default.
• W2153175562 cites W1549647993 @default.
• W2153175562 cites W1569857352 @default.
• W2153175562 cites W1611419331 @default.
• W2153175562 cites W1968987342 @default.
• W2153175562 cites W1979428788 @default.
• W2153175562 cites W1980912932 @default.
• W2153175562 cites W2001684550 @default.
• W2153175562 cites W2017642141 @default.
• W2153175562 cites W2034709592 @default.
• W2153175562 cites W2043641895 @default.
• W2153175562 cites W2047391267 @default.
• W2153175562 cites W2071727569 @default.
• W2153175562 cites W2075413744 @default.
• W2153175562 cites W2081514938 @default.
• W2153175562 cites W2110976740 @default.
• W2153175562 cites W2112349562 @default.
• W2153175562 cites W2115678473 @default.
• W2153175562 cites W2136447541 @default.
• W2153175562 cites W2159520551 @default.
• W2153175562 cites W2160177582 @default.
• W2153175562 cites W4211039187 @default.
• W2153175562 cites W4239629847 @default.
• W2153175562 doi "https://doi.org/10.1261/rna5160904" @default.
• W2153175562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1370513" @default.
• W2153175562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14681580" @default.
• W2153175562 hasPublicationYear "2003" @default.
• W2153175562 type Work @default.
• W2153175562 sameAs 2153175562 @default.
• W2153175562 citedByCount "503" @default.
• W2153175562 countsByYear W21531755622012 @default.
• W2153175562 countsByYear W21531755622013 @default.
• W2153175562 countsByYear W21531755622014 @default.
• W2153175562 countsByYear W21531755622015 @default.
• W2153175562 countsByYear W21531755622016 @default.
• W2153175562 countsByYear W21531755622017 @default.
• W2153175562 countsByYear W21531755622018 @default.
• W2153175562 countsByYear W21531755622019 @default.
• W2153175562 countsByYear W21531755622020 @default.
• W2153175562 countsByYear W21531755622021 @default.
• W2153175562 countsByYear W21531755622022 @default.
• W2153175562 countsByYear W21531755622023 @default.
• W2153175562 crossrefType "journal-article" @default.
• W2153175562 hasAuthorship W2153175562A5006276626 @default.
• W2153175562 hasAuthorship W2153175562A5060605798 @default.
• W2153175562 hasAuthorship W2153175562A5075691104 @default.
• W2153175562 hasBestOaLocation W21531755621 @default.
• W2153175562 hasConcept C104317684 @default.
• W2153175562 hasConcept C119056186 @default.
• W2153175562 hasConcept C150194340 @default.
• W2153175562 hasConcept C153911025 @default.
• W2153175562 hasConcept C165864922 @default.
• W2153175562 hasConcept C166703698 @default.
• W2153175562 hasConcept C2191507 @default.
• W2153175562 hasConcept C22615655 @default.
• W2153175562 hasConcept C54355233 @default.
• W2153175562 hasConcept C60723119 @default.
• W2153175562 hasConcept C67705224 @default.
• W2153175562 hasConcept C86803240 @default.
• W2153175562 hasConcept C95444343 @default.
• W2153175562 hasConceptScore W2153175562C104317684 @default.
• W2153175562 hasConceptScore W2153175562C119056186 @default.
• W2153175562 hasConceptScore W2153175562C150194340 @default.
• W2153175562 hasConceptScore W2153175562C153911025 @default.
• W2153175562 hasConceptScore W2153175562C165864922 @default.
• W2153175562 hasConceptScore W2153175562C166703698 @default.
• W2153175562 hasConceptScore W2153175562C2191507 @default.
• W2153175562 hasConceptScore W2153175562C22615655 @default.
• W2153175562 hasConceptScore W2153175562C54355233 @default.
• W2153175562 hasConceptScore W2153175562C60723119 @default.
• W2153175562 hasConceptScore W2153175562C67705224 @default.
• W2153175562 hasConceptScore W2153175562C86803240 @default.
• W2153175562 hasConceptScore W2153175562C95444343 @default.
• W2153175562 hasIssue "1" @default.
• W2153175562 hasLocation W21531755621 @default.
• W2153175562 hasLocation W21531755622 @default.
• W2153175562 hasLocation W21531755623 @default.
• W2153175562 hasLocation W21531755624 @default.
• W2153175562 hasOpenAccess W2153175562 @default.
• W2153175562 hasPrimaryLocation W21531755621 @default.
• W2153175562 hasRelatedWork W1993956044 @default.
• W2153175562 hasRelatedWork W2070955905 @default.
• W2153175562 hasRelatedWork W2146767638 @default.
• W2153175562 hasRelatedWork W2158423656 @default.
• W2153175562 hasRelatedWork W2372629258 @default.
• W2153175562 hasRelatedWork W2373539659 @default.
• W2153175562 hasRelatedWork W2375286593 @default.
• W2153175562 hasRelatedWork W2516597552 @default.
• W2153175562 hasRelatedWork W2519646246 @default.
• W2153175562 hasRelatedWork W2942195676 @default.
• W2153175562 hasVolume "10" @default.

• next