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- W2153178346 abstract "Latent human immunodeficiency virus type 1 (HIV-1) persists even in patients treated with antiretroviral therapy. New treatment strategies are therefore needed to eradicate this latent viral reservoir without reducing immune cell function. We characterize the interleukin-7 (IL-7)-induced stimulation of primary human T cells and thymocytes and demonstrate, using the SCID-hu model, that IL-7 induces substantial expression of latent HIV while having minimal effects on the cell phenotype. Thus, IL-7 is a viable candidate to activate expression of latent HIV and may facilitate immune clearance of latently infected cells." @default.
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- W2153178346 date "2002-12-15" @default.
- W2153178346 modified "2023-10-16" @default.
- W2153178346 title "Interleukin-7 Induces Expression of Latent Human Immunodeficiency Virus Type 1 with Minimal Effects on T-Cell Phenotype" @default.
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- W2153178346 doi "https://doi.org/10.1128/jvi.76.24.13077-13082.2002" @default.
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