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• W2153188235 abstract "E47 is a helix-loop-helix transcription factor that binds to sites in the immunoglobulin heavy-chain and kappa light-chain gene enhancers. Other proteins of this type are involved in cell-type determination. A possible role for E47 in B-cell development was tested by overexpressing a cDNA encoding E47 in the pre-T-cell line 2017. We found a dramatic activation of a germ-line heavy-chain gene transcript in these stable transfectants and an equally large induction of immunoglobulin D-to-J rearrangement, the first recognized step in B-cell development. Germ-line kappa light-chain gene transcription and rearrangement were unaffected, but transcription of the recombination-activating genes RAG-1 and RAG-2 and the lymphoid-specific transcription factor Oct-2 was increased. These T cells did not transcribe their rearranged DJ alleles, however, and failed to progress to the next stage of heavy-chain gene assembly, V-to-DJ rearrangement. Because transcription factor E47 can induce pre-T cells to carry out events of B-cell differentiation, it may be a crucial determinant of the earliest stages of B-cell development." @default.
• W2153188235 created "2016-06-24" @default.
• W2153188235 creator A5038249166 @default.
• W2153188235 creator A5042763205 @default.
• W2153188235 creator A5089034447 @default.
• W2153188235 date "1991-08-01" @default.
• W2153188235 modified "2023-10-16" @default.
• W2153188235 title "Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line." @default.
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• W2153188235 doi "https://doi.org/10.1101/gad.5.8.1367" @default.
• W2153188235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1714414" @default.
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