FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153193889> ?p ?o ?g. }

• W2153193889 abstract "Paramecium primaurelia is a unicellular eukaryote that moves in freshwater by ciliary beating and responds to environmental stimuli by altering motile behaviour. The movements of the cilia are controlled by the electrical changes of the cell membrane: when the intraciliary Ca(2+) concentration associated with plasma membrane depolarization increases, the ciliary beating reverses its direction, and consequently the swimming direction changes. The ciliary reversal duration is correlated with the amount of Ca(2+) influx. Here, we evaluated the effects due to the activation or blockade of N-methyl-d-aspartic acid (NMDA) receptors on swimming behaviour in Paramecium. Paramecia normally swim forward, drawing almost linear tracks. We observed that the simultaneous administration of NMDA and glycine induced a partial ciliary reversal (PaCR) leading to a continuous spiral-like swim. Furthermore, the duration of continuous ciliary reversal (CCR), triggered by high external KCl concentrations, was longer in NMDA+glycine-treated cells. NMDA action required the presence of Ca(2+), as the normal forward swimming was restored when the ion was omitted from the extracellular milieu. The PaCR and the enhancement of CCR duration significantly decreased when the antagonists of the glutamate site D-AP5 or CGS19755, the NMDA channel blocker MK-801 or the glycine site antagonist DCKA was added. The action of NMDA+glycine was also abolished by Zn(2+) or ifenprodil, the GluN2A and the GluN2B NMDA-containing subunit blockers, respectively. Searches of the Paramecium genome database currently available indicate that the NMDA-like receptor with ligand-binding characteristics of an NMDA receptor-like complex, purified from rat brain synaptic membranes and found in some metazoan genomes, is also present in Paramecium. These results provide evidence that functional NMDA receptors similar to those typical of mammalian neuronal cells are present in the single-celled organism Paramecium and thus suggest that the glutamatergic NMDA system is a phylogenetically old behaviour-controlling mechanism." @default.
• W2153193889 created "2016-06-24" @default.
• W2153193889 creator A5015365959 @default.
• W2153193889 creator A5031882730 @default.
• W2153193889 creator A5035212947 @default.
• W2153193889 creator A5037244801 @default.
• W2153193889 creator A5048232498 @default.
• W2153193889 creator A5054790814 @default.
• W2153193889 creator A5076444958 @default.
• W2153193889 creator A5081582944 @default.
• W2153193889 creator A5087593953 @default.
• W2153193889 date "2013-01-01" @default.
• W2153193889 modified "2023-10-18" @default.
• W2153193889 title "Pharmacological characterization of N-methyl-d-aspartic acid (NMDA)-like receptors in the single-celled organism<i>Paramecium primaurelia</i>" @default.
• W2153193889 cites W1519266993 @default.
• W2153193889 cites W1594510334 @default.
• W2153193889 cites W1605215937 @default.
• W2153193889 cites W164660242 @default.
• W2153193889 cites W1656913045 @default.
• W2153193889 cites W1793612468 @default.
• W2153193889 cites W1860466396 @default.
• W2153193889 cites W1917307447 @default.
• W2153193889 cites W1968754632 @default.
• W2153193889 cites W1970112108 @default.
• W2153193889 cites W1975342713 @default.
• W2153193889 cites W1977237836 @default.
• W2153193889 cites W1979286553 @default.
• W2153193889 cites W1986206610 @default.
• W2153193889 cites W1986836721 @default.
• W2153193889 cites W1988893923 @default.
• W2153193889 cites W1991899167 @default.
• W2153193889 cites W1991902653 @default.
• W2153193889 cites W1997568797 @default.
• W2153193889 cites W2000023875 @default.
• W2153193889 cites W2001189298 @default.
• W2153193889 cites W2004800224 @default.
• W2153193889 cites W2006081558 @default.
• W2153193889 cites W2006541920 @default.
• W2153193889 cites W2010926499 @default.
• W2153193889 cites W2012641732 @default.
• W2153193889 cites W2018878425 @default.
• W2153193889 cites W2019416392 @default.
• W2153193889 cites W2022830828 @default.
• W2153193889 cites W2024921008 @default.
• W2153193889 cites W2027251110 @default.
• W2153193889 cites W2034189126 @default.
• W2153193889 cites W2035448076 @default.
• W2153193889 cites W2037852973 @default.
• W2153193889 cites W2038770898 @default.
• W2153193889 cites W2039200277 @default.
• W2153193889 cites W2041426722 @default.
• W2153193889 cites W2051712077 @default.
• W2153193889 cites W2054946491 @default.
• W2153193889 cites W2061038419 @default.
• W2153193889 cites W2062928716 @default.
• W2153193889 cites W2064197376 @default.
• W2153193889 cites W2067669919 @default.
• W2153193889 cites W2070261892 @default.
• W2153193889 cites W2070702079 @default.
• W2153193889 cites W2070808117 @default.
• W2153193889 cites W2073111128 @default.
• W2153193889 cites W2076631476 @default.
• W2153193889 cites W2078662595 @default.
• W2153193889 cites W2084137458 @default.
• W2153193889 cites W2087204472 @default.
• W2153193889 cites W2089619207 @default.
• W2153193889 cites W2090191015 @default.
• W2153193889 cites W2091730749 @default.
• W2153193889 cites W2105752803 @default.
• W2153193889 cites W2114508605 @default.
• W2153193889 cites W2118833414 @default.
• W2153193889 cites W2119520301 @default.
• W2153193889 cites W2121624942 @default.
• W2153193889 cites W2124439293 @default.
• W2153193889 cites W2128379918 @default.
• W2153193889 cites W2138817668 @default.
• W2153193889 cites W2157805785 @default.
• W2153193889 cites W2158714788 @default.
• W2153193889 cites W2164469401 @default.
• W2153193889 cites W2178121338 @default.
• W2153193889 cites W2184264811 @default.
• W2153193889 cites W2189071416 @default.
• W2153193889 cites W2251934936 @default.
• W2153193889 cites W2341728909 @default.
• W2153193889 cites W2797946562 @default.
• W2153193889 doi "https://doi.org/10.1242/jeb.093914" @default.
• W2153193889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24143028" @default.
• W2153193889 hasPublicationYear "2013" @default.
• W2153193889 type Work @default.
• W2153193889 sameAs 2153193889 @default.
• W2153193889 citedByCount "10" @default.
• W2153193889 countsByYear W21531938892015 @default.
• W2153193889 countsByYear W21531938892016 @default.
• W2153193889 countsByYear W21531938892017 @default.
• W2153193889 countsByYear W21531938892018 @default.
• W2153193889 countsByYear W21531938892021 @default.
• W2153193889 countsByYear W21531938892022 @default.
• W2153193889 crossrefType "journal-article" @default.
• W2153193889 hasAuthorship W2153193889A5015365959 @default.
• W2153193889 hasAuthorship W2153193889A5031882730 @default.

• next