FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153200821> ?p ?o ?g. }

• W2153200821 endingPage "298" @default.
• W2153200821 startingPage "291" @default.
• W2153200821 abstract "5-HT6 receptors have been implicated in consolidation of visuospatial and reward-based learning tasks. Since 5-HT6 receptors may be important in modulation of sensory gating which is often affected in schizophrenic patients, we tested whether Ro 4368554, a 5-HT6 selective antagonist at a dose of 10 mg/kg, could reverse the loss of prepulse inhibition from apomorphine or scopolamine. In addition, we also tested whether Ro 4368554 altered fear conditioning using fear potentiated startle, a model for emotional learning. Prepulse inhibition of startle was disrupted by apomorphine (0.5 mg/kg) when prepulse emissions were 5 dB above background but not above 15 dB, while scopolamine (0.5 mg/kg) caused disruption at both prepulse levels. Scopolamine-mediated disruption was not reversed by Ro 4368854 but apomorphine-mediated disruption was significantly ameliorated by 5-HT6 inhibition. For fear potentiated startle, scopolamine and/or Ro 4368554 were administered before two daily fear conditioning sessions; rats were tested on the following day. Rats that received scopolamine displayed no fear potentiated startle but Ro 4368554 reversed this scopolamine deficit. Additionally, we mapped Fos induction in rats treated with scopolamine and/or Ro 4368554; scopolamine increased Fos expression in the central nucleus of the amygdala and this was attenuated by Ro 4368554. In summary, we have demonstrated the efficacy of 5-HT6 antagonists in modulating sensory gating and fear conditioning, and thus may be of therapeutic use for schizophrenia-related disorders." @default.
• W2153200821 created "2016-06-24" @default.
• W2153200821 creator A5083753778 @default.
• W2153200821 creator A5084290098 @default.
• W2153200821 date "2008-01-01" @default.
• W2153200821 modified "2023-09-27" @default.
• W2153200821 title "5-HT6 receptor antagonist reversal of emotional learning and prepulse inhibition deficits induced by apomorphine or scopolamine" @default.
• W2153200821 cites W1963976940 @default.
• W2153200821 cites W1971925053 @default.
• W2153200821 cites W1981382028 @default.
• W2153200821 cites W1984304181 @default.
• W2153200821 cites W1985254321 @default.
• W2153200821 cites W1985437286 @default.
• W2153200821 cites W1989480031 @default.
• W2153200821 cites W1989505370 @default.
• W2153200821 cites W1995953249 @default.
• W2153200821 cites W1997337458 @default.
• W2153200821 cites W1998299683 @default.
• W2153200821 cites W1998570794 @default.
• W2153200821 cites W1998711891 @default.
• W2153200821 cites W2003692568 @default.
• W2153200821 cites W2005756201 @default.
• W2153200821 cites W2006421350 @default.
• W2153200821 cites W2008126685 @default.
• W2153200821 cites W2008145156 @default.
• W2153200821 cites W2011182878 @default.
• W2153200821 cites W2013813099 @default.
• W2153200821 cites W2020284109 @default.
• W2153200821 cites W2022901159 @default.
• W2153200821 cites W2022961682 @default.
• W2153200821 cites W2028280475 @default.
• W2153200821 cites W2028428443 @default.
• W2153200821 cites W2028541643 @default.
• W2153200821 cites W2052923849 @default.
• W2153200821 cites W2064174861 @default.
• W2153200821 cites W2068480458 @default.
• W2153200821 cites W2076240748 @default.
• W2153200821 cites W2076977175 @default.
• W2153200821 cites W2077604455 @default.
• W2153200821 cites W2082541743 @default.
• W2153200821 cites W2083445063 @default.
• W2153200821 cites W2090424711 @default.
• W2153200821 cites W2095460819 @default.
• W2153200821 cites W2106933585 @default.
• W2153200821 cites W2123262275 @default.
• W2153200821 cites W2138324540 @default.
• W2153200821 cites W2141303219 @default.
• W2153200821 cites W2144729301 @default.
• W2153200821 cites W2161632903 @default.
• W2153200821 cites W2163815564 @default.
• W2153200821 cites W2167030221 @default.
• W2153200821 cites W2398650533 @default.
• W2153200821 doi "https://doi.org/10.1016/j.pbb.2007.08.015" @default.
• W2153200821 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2322863" @default.
• W2153200821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17920665" @default.
• W2153200821 hasPublicationYear "2008" @default.
• W2153200821 type Work @default.
• W2153200821 sameAs 2153200821 @default.
• W2153200821 citedByCount "30" @default.
• W2153200821 countsByYear W21532008212012 @default.
• W2153200821 countsByYear W21532008212013 @default.
• W2153200821 countsByYear W21532008212014 @default.
• W2153200821 countsByYear W21532008212015 @default.
• W2153200821 countsByYear W21532008212016 @default.
• W2153200821 countsByYear W21532008212017 @default.
• W2153200821 countsByYear W21532008212018 @default.
• W2153200821 countsByYear W21532008212019 @default.
• W2153200821 crossrefType "journal-article" @default.
• W2153200821 hasAuthorship W2153200821A5083753778 @default.
• W2153200821 hasAuthorship W2153200821A5084290098 @default.
• W2153200821 hasBestOaLocation W21532008212 @default.
• W2153200821 hasConcept C118552586 @default.
• W2153200821 hasConcept C126322002 @default.
• W2153200821 hasConcept C137183658 @default.
• W2153200821 hasConcept C141421786 @default.
• W2153200821 hasConcept C15744967 @default.
• W2153200821 hasConcept C16837860 @default.
• W2153200821 hasConcept C169760540 @default.
• W2153200821 hasConcept C170493617 @default.
• W2153200821 hasConcept C194544171 @default.
• W2153200821 hasConcept C2776412080 @default.
• W2153200821 hasConcept C2776885963 @default.
• W2153200821 hasConcept C2777525119 @default.
• W2153200821 hasConcept C2779144063 @default.
• W2153200821 hasConcept C2779705967 @default.
• W2153200821 hasConcept C2909050532 @default.
• W2153200821 hasConcept C33789571 @default.
• W2153200821 hasConcept C513476851 @default.
• W2153200821 hasConcept C71924100 @default.
• W2153200821 hasConcept C98274493 @default.
• W2153200821 hasConceptScore W2153200821C118552586 @default.
• W2153200821 hasConceptScore W2153200821C126322002 @default.
• W2153200821 hasConceptScore W2153200821C137183658 @default.
• W2153200821 hasConceptScore W2153200821C141421786 @default.
• W2153200821 hasConceptScore W2153200821C15744967 @default.
• W2153200821 hasConceptScore W2153200821C16837860 @default.
• W2153200821 hasConceptScore W2153200821C169760540 @default.
• W2153200821 hasConceptScore W2153200821C170493617 @default.

• next