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• W2153209580 abstract "Abstract Magnetic resonance imaging has shown promise for evaluating tissue oxygenation. In this study differences in the tissue longitudinal relaxation rate ( R 1 ) and effective transverse relaxation rate ( R ), induced by inhalation of pure oxygen and carbogen, were evaluated in 10 healthy subjects. Significant reductions in R 1 were demonstrated following both oxygen and carbogen inhalation in the spleen (both P < 0.001), liver ( P = 0.002 air vs. oxygen; P = 0.001 air vs. carbogen), skeletal muscle (both P < 0.001), and renal cortex ( P = 0.005 air vs. oxygen; P = 0.008 air vs. carbogen). No significant change in R occurred following pure oxygen in any organ. However, a significant increase in R was observed in the spleen ( P < 0.001), liver ( P = 0.001), skeletal muscle ( P = 0.026), and renal cortex ( P = 0.001) following carbogen inhalation, an opposite effect to that observed in many studies of tumor pathophysiology. Changes in R 1 and R were independent of the gas administration order in the spleen and skeletal muscle. These findings suggest that the R 1 and R responses to hyperoxic gases are independent biomarkers of oxygen physiology. Magn Reson Med 61:75–83, 2009. © 2008 Wiley‐Liss, Inc." @default.
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• W2153209580 date "2008-12-18" @default.
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• W2153209580 title "Comparison of normal tissue <i>R</i>_<i>1</i> and <i>R</i> modulation by oxygen and carbogen" @default.
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• W2153209580 doi "https://doi.org/10.1002/mrm.21815" @default.
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