FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153226682> ?p ?o ?g. }

• W2153226682 endingPage "5185" @default.
• W2153226682 startingPage "5179" @default.
• W2153226682 abstract "Abstract Viperin is an antiviral protein whose expression is highly upregulated during viral infections via IFN-dependent and/or IFN-independent pathways. We examined the molecular alterations induced by the transcriptional activator IFN regulatory factor (IRF)-1 and found viperin to be among the group of IRF-1 regulated genes. From these data, it was not possible to distinguish genes that are primary targets of IRF-1 and those that are targets of IRF-1–induced proteins, like IFN-β. In this study, we show that IRF-1 directly binds to the murine viperin promoter to the two proximal IRF elements and thereby induces viperin expression. Infection studies with embryonal fibroblasts from different gene knock-out mice demonstrate that IRF-1 is essential, whereas the type I IFN system is dispensable for vesicular stomatitis virus induced viperin gene transcription. Further, IRF-1, but not IFN type I, mediates the induction of viperin transcription after IFN-γ treatment. In contrast, IRF-1 is not required for IFN-independent viperin induction by Newcastle disease virus infection and by infection with a vesicular stomatitis virus mutant that is unable to block IFN expression and secretion. We conclude that the IRF-1 mediated type I IFN independent mechanism of enhanced viperin expression provides a redundant mechanism to protect cells from viral infections. This mechanism becomes important when viruses evade innate immunity by antagonizing the induction and function of the IFN system." @default.
• W2153226682 created "2016-06-24" @default.
• W2153226682 creator A5044189138 @default.
• W2153226682 creator A5060373190 @default.
• W2153226682 creator A5061655234 @default.
• W2153226682 creator A5067066734 @default.
• W2153226682 creator A5074419893 @default.
• W2153226682 creator A5080639659 @default.
• W2153226682 creator A5091704443 @default.
• W2153226682 date "2010-05-01" @default.
• W2153226682 modified "2023-10-02" @default.
• W2153226682 title "IFN Regulatory Factor-1 Bypasses IFN-Mediated Antiviral Effects through Viperin Gene Induction" @default.
• W2153226682 cites W1510347472 @default.
• W2153226682 cites W1607445214 @default.
• W2153226682 cites W1655903008 @default.
• W2153226682 cites W1885803373 @default.
• W2153226682 cites W1909433302 @default.
• W2153226682 cites W1973701834 @default.
• W2153226682 cites W1975519799 @default.
• W2153226682 cites W2002774545 @default.
• W2153226682 cites W2015141576 @default.
• W2153226682 cites W2018898580 @default.
• W2153226682 cites W2021951044 @default.
• W2153226682 cites W2027147867 @default.
• W2153226682 cites W2029765622 @default.
• W2153226682 cites W2032908627 @default.
• W2153226682 cites W2036767516 @default.
• W2153226682 cites W2050963689 @default.
• W2153226682 cites W2052932569 @default.
• W2153226682 cites W2053270830 @default.
• W2153226682 cites W2058122617 @default.
• W2153226682 cites W2063040170 @default.
• W2153226682 cites W2076007552 @default.
• W2153226682 cites W2078319759 @default.
• W2153226682 cites W2092498488 @default.
• W2153226682 cites W2099567406 @default.
• W2153226682 cites W2100396313 @default.
• W2153226682 cites W2101271083 @default.
• W2153226682 cites W2114238965 @default.
• W2153226682 cites W2119195058 @default.
• W2153226682 cites W2133003425 @default.
• W2153226682 cites W2150558072 @default.
• W2153226682 cites W2150701651 @default.
• W2153226682 cites W2155095982 @default.
• W2153226682 cites W2162440799 @default.
• W2153226682 cites W2162632202 @default.
• W2153226682 cites W2172170043 @default.
• W2153226682 doi "https://doi.org/10.4049/jimmunol.0902264" @default.
• W2153226682 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20308629" @default.
• W2153226682 hasPublicationYear "2010" @default.
• W2153226682 type Work @default.
• W2153226682 sameAs 2153226682 @default.
• W2153226682 citedByCount "111" @default.
• W2153226682 countsByYear W21532266822012 @default.
• W2153226682 countsByYear W21532266822013 @default.
• W2153226682 countsByYear W21532266822014 @default.
• W2153226682 countsByYear W21532266822015 @default.
• W2153226682 countsByYear W21532266822016 @default.
• W2153226682 countsByYear W21532266822017 @default.
• W2153226682 countsByYear W21532266822018 @default.
• W2153226682 countsByYear W21532266822019 @default.
• W2153226682 countsByYear W21532266822020 @default.
• W2153226682 countsByYear W21532266822021 @default.
• W2153226682 countsByYear W21532266822022 @default.
• W2153226682 countsByYear W21532266822023 @default.
• W2153226682 crossrefType "journal-article" @default.
• W2153226682 hasAuthorship W2153226682A5044189138 @default.
• W2153226682 hasAuthorship W2153226682A5060373190 @default.
• W2153226682 hasAuthorship W2153226682A5061655234 @default.
• W2153226682 hasAuthorship W2153226682A5067066734 @default.
• W2153226682 hasAuthorship W2153226682A5074419893 @default.
• W2153226682 hasAuthorship W2153226682A5080639659 @default.
• W2153226682 hasAuthorship W2153226682A5091704443 @default.
• W2153226682 hasBestOaLocation W21532266821 @default.
• W2153226682 hasConcept C104317684 @default.
• W2153226682 hasConcept C136449434 @default.
• W2153226682 hasConcept C159047783 @default.
• W2153226682 hasConcept C165864922 @default.
• W2153226682 hasConcept C203014093 @default.
• W2153226682 hasConcept C2522874641 @default.
• W2153226682 hasConcept C2776178377 @default.
• W2153226682 hasConcept C2776966659 @default.
• W2153226682 hasConcept C2779057330 @default.
• W2153226682 hasConcept C32300475 @default.
• W2153226682 hasConcept C54355233 @default.
• W2153226682 hasConcept C86339819 @default.
• W2153226682 hasConcept C86803240 @default.
• W2153226682 hasConcept C8891405 @default.
• W2153226682 hasConcept C9173399 @default.
• W2153226682 hasConcept C95444343 @default.
• W2153226682 hasConceptScore W2153226682C104317684 @default.
• W2153226682 hasConceptScore W2153226682C136449434 @default.
• W2153226682 hasConceptScore W2153226682C159047783 @default.
• W2153226682 hasConceptScore W2153226682C165864922 @default.
• W2153226682 hasConceptScore W2153226682C203014093 @default.
• W2153226682 hasConceptScore W2153226682C2522874641 @default.
• W2153226682 hasConceptScore W2153226682C2776178377 @default.
• W2153226682 hasConceptScore W2153226682C2776966659 @default.

• next