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• W2153248854 abstract "The goal of this study was to determine the contribution of bone marrow-derived circulating endothelial progenitorcellstotheformationofendothelialcellliningsof tumor vessel walls.The proportion of male endothelial cells infemaleJCandWEHItumorswasmeasuredinmaleBALB/c mice and in female mice displaying complete marrow chimerism, after receiving male bone marrow cells. The gender origin of the perivascular endothelial cells w as determined by fluorescent in situ hybridization (FISH) analysis of adjacent cuts of the tumors, using CD31 andY- chromosomesasmarkers.Highproportionsofmalecellswere detectedintheperivascularendothelialcellliningsoftheJC (60±4%)andWEHI(67±4%)tumorsafterimplantationinto normal male mice. Furthermore, in marrow chimeric female mice, very high levels of male cells were observed in the endothelilal cell linings of the tumor vessel walls of both tumortypes,afterbonemarrowtransplantation.Weconclude thatJCandWEHItumorscanserveasamurineexperimental model and that bone marrow cells from these can be manipulatedandculturedinvitroforuseinstudiesoftumor vesselwallsaftertransplantationintomyeloablatedrecipients. For oxygenation, nutrient supply and to enable metastasis, most tumors depend on their capacity to connect to the blood circulation. Tumor cells release angiogenic signals which attract and stimulate endothelial cells to construct capillaries within the tumor. Compared to embryonic vasculogenesis, the formation of tumor blood vessel branches is unordered due to high energy demands during exponential tumor growth. The cells of tumor vessel walls vary between tumor types and even between different areas within a single tumor. Most tumor types contain vessels with endothelial cell linings consisting of genetically normal, non-malignant cells. These cell configurations are usually found within a short distance of the regular vascular system. Malignant cells, however, may be interspersed throughout the endothelial cell lining and have direct contact with the blood, forming mosaic vessels (1). Certain tumors or tumor regions are further away from vascular junctions and possess the capacity to form vascular channels, which are pseudovessels formed mostly by tumor cells (2-7). It is important that the molecular and cellular events that lead to angiogenesis are understood, particularly because of the potential therapeutical implications. A variety of cytokines and proangiogenic factors, such as vascular endothelial growth factor, initiate endothelial cell growth within the tumor mass and the resulting capillaries forge direct connections with the existing normal vasculature (8). The origin of the normal cells that are found within tumors is disputed. Endothelial precursor cells (EPC) adhere to the endothelium when stimulated by angiogenic factors and play a role in physiologic vessel regeneration and reparation, and these have been identified in tumors. Circulating EPCs originate from a stem/progenitor cell pool that may be present within the bone marrow. As for all putative hemangiopoietic cell types, there is controversy about their origin. Somatic endothelial stem cells potentially reside in the bone marrow, but other stem/progenitor cells of the hematopoietic cell lines may have the capacity to transdifferentiate into EPC types. Bone marrow cells are easily procured by aspiration and can be maintained in culture forinvitro manipulations and may be later reinserted into the organism by intravenous injection. Thus, if endothelial cell linings of malignant tumors are derived from cells originating from bone marrow cells, this would offer a relatively easy way to deliver therapeutic agents to a tumor. Because bone marrow tissue contains a wide variety of progenitor cells, including endothelial precursors, we" @default.
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• W2153248854 date "2008-03-01" @default.
• W2153248854 modified "2023-09-28" @default.
• W2153248854 title "Bone marrow-derived endothelial cells contribute to angiogenesis in murine WEHI and JC tumors." @default.
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