FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153259404> ?p ?o ?g. }

• W2153259404 endingPage "184" @default.
• W2153259404 startingPage "177" @default.
• W2153259404 abstract "Ornithine decarboxylase (ODC) and its polyamine end-products have been suggested to play important roles in outgrowth and function of central neurons. ODC displays high activity in neonatal rat brain followed by a rapid decline to the low levels characteristic of mature brain. The mechanisms underlying this developmental pattern were found to involve transcriptional, translational and post-translational factors. Inhibition of transcription with actinomycin D led to a more rapid loss of ODC activity in 2 day old rats when compared to 10 day olds, indicating a greater dependence on ongoing RNA synthesis to maintain the higher activity in the younger rats. Inhibition of translation with cycloheximide produced a slower rate of decline of ODC in the younger animals: these data indicate that the higher ODC seen early in development is due in part to a greater rate of transcription of RNA coding for ODC (greater actinomycin D sensitivity) combined with a slower rate of degradation of enzyme activity (slower loss after cycloheximide). In keeping with the concept that the maturational dimunution of ODC involves a reduction in the amount of enzyme present, kinetic studies revealed a decline in the enzyme Vmax between 2 days and 10 days of age; unlike the situation for ODC in developing heart tissue, there was no evidence for a maturational shift in Kmorn. Similarly, dexamethasone treatment, which reduces brain ODC and causes consequent defects in synaptogenesis, produced the ODC deficit through reductions in Vmax without alterations in Kmorn. Results of mixing and dialysis experiments with neonatal and adult ODC preparations suggested that additional post-translational regulation of brain ODC activity takes place, involving a dialyzable activator in the neonate and a non-dialyzable inhibitor in the adult. Thus, the higher brain ODC activity seen at 2 days appears to be due to a greater rate of enzyme formation and slowed degradation, combined with post-translational activation of the activity; the developmental decline in ODC reflects a reduction in the amount of enzyme along with loss of the post-translational activator and appearance of an inhibitor." @default.
• W2153259404 created "2016-06-24" @default.
• W2153259404 creator A5000464378 @default.
• W2153259404 creator A5025888777 @default.
• W2153259404 creator A5069122773 @default.
• W2153259404 date "1983-03-01" @default.
• W2153259404 modified "2023-10-17" @default.
• W2153259404 title "Regulation of brain ornithine decarboxylase activity in the neonatal rat" @default.
• W2153259404 cites W1576879289 @default.
• W2153259404 cites W170491672 @default.
• W2153259404 cites W1966288743 @default.
• W2153259404 cites W1980787599 @default.
• W2153259404 cites W2000057578 @default.
• W2153259404 cites W2007566657 @default.
• W2153259404 cites W2010390575 @default.
• W2153259404 cites W2020911796 @default.
• W2153259404 cites W2037695453 @default.
• W2153259404 cites W2050902768 @default.
• W2153259404 cites W2059468057 @default.
• W2153259404 cites W2061290807 @default.
• W2153259404 cites W2064911865 @default.
• W2153259404 cites W2074345530 @default.
• W2153259404 cites W2075071690 @default.
• W2153259404 cites W2114290698 @default.
• W2153259404 cites W2127507629 @default.
• W2153259404 cites W2127952009 @default.
• W2153259404 cites W4323966420 @default.
• W2153259404 doi "https://doi.org/10.1016/0014-2999(83)90004-3" @default.
• W2153259404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6852109" @default.
• W2153259404 hasPublicationYear "1983" @default.
• W2153259404 type Work @default.
• W2153259404 sameAs 2153259404 @default.
• W2153259404 citedByCount "7" @default.
• W2153259404 crossrefType "journal-article" @default.
• W2153259404 hasAuthorship W2153259404A5000464378 @default.
• W2153259404 hasAuthorship W2153259404A5025888777 @default.
• W2153259404 hasAuthorship W2153259404A5069122773 @default.
• W2153259404 hasConcept C108905728 @default.
• W2153259404 hasConcept C121289238 @default.
• W2153259404 hasConcept C126322002 @default.
• W2153259404 hasConcept C134018914 @default.
• W2153259404 hasConcept C138885662 @default.
• W2153259404 hasConcept C179926584 @default.
• W2153259404 hasConcept C181199279 @default.
• W2153259404 hasConcept C2777167505 @default.
• W2153259404 hasConcept C2778128677 @default.
• W2153259404 hasConcept C3675279 @default.
• W2153259404 hasConcept C41895202 @default.
• W2153259404 hasConcept C55493867 @default.
• W2153259404 hasConcept C65232495 @default.
• W2153259404 hasConcept C71924100 @default.
• W2153259404 hasConcept C86803240 @default.
• W2153259404 hasConcept C95444343 @default.
• W2153259404 hasConceptScore W2153259404C108905728 @default.
• W2153259404 hasConceptScore W2153259404C121289238 @default.
• W2153259404 hasConceptScore W2153259404C126322002 @default.
• W2153259404 hasConceptScore W2153259404C134018914 @default.
• W2153259404 hasConceptScore W2153259404C138885662 @default.
• W2153259404 hasConceptScore W2153259404C179926584 @default.
• W2153259404 hasConceptScore W2153259404C181199279 @default.
• W2153259404 hasConceptScore W2153259404C2777167505 @default.
• W2153259404 hasConceptScore W2153259404C2778128677 @default.
• W2153259404 hasConceptScore W2153259404C3675279 @default.
• W2153259404 hasConceptScore W2153259404C41895202 @default.
• W2153259404 hasConceptScore W2153259404C55493867 @default.
• W2153259404 hasConceptScore W2153259404C65232495 @default.
• W2153259404 hasConceptScore W2153259404C71924100 @default.
• W2153259404 hasConceptScore W2153259404C86803240 @default.
• W2153259404 hasConceptScore W2153259404C95444343 @default.
• W2153259404 hasIssue "2-3" @default.
• W2153259404 hasLocation W21532594041 @default.
• W2153259404 hasLocation W21532594042 @default.
• W2153259404 hasOpenAccess W2153259404 @default.
• W2153259404 hasPrimaryLocation W21532594041 @default.
• W2153259404 hasRelatedWork W1806097919 @default.
• W2153259404 hasRelatedWork W2006086030 @default.
• W2153259404 hasRelatedWork W2050902768 @default.
• W2153259404 hasRelatedWork W2052859192 @default.
• W2153259404 hasRelatedWork W2067016788 @default.
• W2153259404 hasRelatedWork W2076983860 @default.
• W2153259404 hasRelatedWork W2092478584 @default.
• W2153259404 hasRelatedWork W2143548241 @default.
• W2153259404 hasRelatedWork W2153259404 @default.
• W2153259404 hasRelatedWork W2345067921 @default.
• W2153259404 hasVolume "88" @default.
• W2153259404 isParatext "false" @default.
• W2153259404 isRetracted "false" @default.
• W2153259404 magId "2153259404" @default.
• W2153259404 workType "article" @default.