Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153259779> ?p ?o ?g. }
- W2153259779 endingPage "81" @default.
- W2153259779 startingPage "68" @default.
- W2153259779 abstract "Multiple system atrophy (MSA) exhibits widespread astrogliosis together with α-synuclein (α-syn) glial cytoplasmic inclusions (GCIs) in mature oligodendrocytes. We quantified astrocyte activation by morphometric analysis of MSA cases, and investigated the correlation to GCI proximity. Using Imaris software, we obtained “skinned” three-dimensional models of GFAP-positive astrocytes in MSA and control tissue (n = 75) from confocal z-stacks and measured the astrocyte process length and thickness and radial distance to the GCI. Astrocytes proximal to GCI-containing oligodendrocytes (r < 25 μm) had significantly (p, 0.05) longer and thicker processes characteristic of activation than distal astrocytes (r > 25 μm), with a reciprocal linear correlation (m, 90 μm2) between mean process length and radial distance to the nearest GCI (R2, 0.7). In primary cell culture studies, α-syn addition caused ERK-dependent activation of rat astrocytes and perinuclear α-syn inclusions in mature (MOSP-positive) rat oligodendrocytes. Activated astrocytes were also observed in close proximity to α-syn deposits in a unilateral rotenone-lesion mouse model. Moreover, unilateral injection of MSA tissue-derived α-syn into the mouse medial forebrain bundle resulted in widespread neuroinflammation in the α-syn-injected, but not sham-injected hemisphere. Taken together, our data suggests that the action of localized concentrations of α-syn may underlie both astrocyte and oligodendrocyte MSA pathological features." @default.
- W2153259779 created "2016-06-24" @default.
- W2153259779 creator A5000428113 @default.
- W2153259779 creator A5007307080 @default.
- W2153259779 creator A5010893750 @default.
- W2153259779 creator A5012969008 @default.
- W2153259779 creator A5017039332 @default.
- W2153259779 creator A5028353316 @default.
- W2153259779 creator A5028848778 @default.
- W2153259779 creator A5030829136 @default.
- W2153259779 creator A5034301612 @default.
- W2153259779 creator A5035819588 @default.
- W2153259779 creator A5041419352 @default.
- W2153259779 creator A5043168275 @default.
- W2153259779 creator A5046541192 @default.
- W2153259779 creator A5075562396 @default.
- W2153259779 creator A5090647382 @default.
- W2153259779 date "2015-03-01" @default.
- W2153259779 modified "2023-09-26" @default.
- W2153259779 title "The degree of astrocyte activation in multiple system atrophy is inversely proportional to the distance to α-synuclein inclusions" @default.
- W2153259779 cites W1509052415 @default.
- W2153259779 cites W1519095619 @default.
- W2153259779 cites W1547937746 @default.
- W2153259779 cites W1581206995 @default.
- W2153259779 cites W1583433785 @default.
- W2153259779 cites W173382140 @default.
- W2153259779 cites W1786270771 @default.
- W2153259779 cites W1807507622 @default.
- W2153259779 cites W1853679464 @default.
- W2153259779 cites W1922424218 @default.
- W2153259779 cites W1968957266 @default.
- W2153259779 cites W1973608140 @default.
- W2153259779 cites W1978525572 @default.
- W2153259779 cites W1978865621 @default.
- W2153259779 cites W1982663316 @default.
- W2153259779 cites W1983153401 @default.
- W2153259779 cites W1984688042 @default.
- W2153259779 cites W1985228085 @default.
- W2153259779 cites W1986625112 @default.
- W2153259779 cites W1998634021 @default.
- W2153259779 cites W1999883522 @default.
- W2153259779 cites W2013307195 @default.
- W2153259779 cites W2016974059 @default.
- W2153259779 cites W2018021845 @default.
- W2153259779 cites W2019863741 @default.
- W2153259779 cites W2024919859 @default.
- W2153259779 cites W2031211619 @default.
- W2153259779 cites W2031841983 @default.
- W2153259779 cites W2033022767 @default.
- W2153259779 cites W2033402586 @default.
- W2153259779 cites W2035318781 @default.
- W2153259779 cites W2042224862 @default.
- W2153259779 cites W2045924744 @default.
- W2153259779 cites W2046885195 @default.
- W2153259779 cites W2048008062 @default.
- W2153259779 cites W2049466618 @default.
- W2153259779 cites W2050235993 @default.
- W2153259779 cites W2051126370 @default.
- W2153259779 cites W2052118189 @default.
- W2153259779 cites W2057121960 @default.
- W2153259779 cites W2059994807 @default.
- W2153259779 cites W2065426913 @default.
- W2153259779 cites W2067267561 @default.
- W2153259779 cites W2073860579 @default.
- W2153259779 cites W2075906033 @default.
- W2153259779 cites W2080243097 @default.
- W2153259779 cites W2083488837 @default.
- W2153259779 cites W2083700414 @default.
- W2153259779 cites W2085906978 @default.
- W2153259779 cites W2089855415 @default.
- W2153259779 cites W2090840175 @default.
- W2153259779 cites W2100039520 @default.
- W2153259779 cites W2103976813 @default.
- W2153259779 cites W2113481924 @default.
- W2153259779 cites W2118221606 @default.
- W2153259779 cites W2125447215 @default.
- W2153259779 cites W2136659930 @default.
- W2153259779 cites W2146858419 @default.
- W2153259779 cites W2149602553 @default.
- W2153259779 cites W2154616452 @default.
- W2153259779 cites W2156016220 @default.
- W2153259779 cites W2158181315 @default.
- W2153259779 cites W2158406932 @default.
- W2153259779 cites W2160935383 @default.
- W2153259779 cites W2162240955 @default.
- W2153259779 cites W2307330333 @default.
- W2153259779 doi "https://doi.org/10.1016/j.mcn.2015.02.015" @default.
- W2153259779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25731829" @default.
- W2153259779 hasPublicationYear "2015" @default.
- W2153259779 type Work @default.
- W2153259779 sameAs 2153259779 @default.
- W2153259779 citedByCount "48" @default.
- W2153259779 countsByYear W21532597792015 @default.
- W2153259779 countsByYear W21532597792016 @default.
- W2153259779 countsByYear W21532597792017 @default.
- W2153259779 countsByYear W21532597792018 @default.
- W2153259779 countsByYear W21532597792019 @default.
- W2153259779 countsByYear W21532597792020 @default.