FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153274979> ?p ?o ?g. }

• W2153274979 endingPage "e83903" @default.
• W2153274979 startingPage "e83903" @default.
• W2153274979 abstract "A growing body of research indicates that pharmacological inhibition of histone deacetylases (HDACs) correlates with enhancement of long-term memory and current research is concentrated on determining the roles that individual HDACs play in cognitive function. Here, we investigate the role of HDAC4 in long-term memory formation in Drosophila. We show that overexpression of HDAC4 in the adult mushroom body, an important structure for memory formation, resulted in a specific impairment in long-term courtship memory, but had no affect on short-term memory. Overexpression of an HDAC4 catalytic mutant also abolished LTM, suggesting a mode of action independent of catalytic activity. We found that overexpression of HDAC4 resulted in a redistribution of the transcription factor MEF2 from a relatively uniform distribution through the nucleus into punctate nuclear bodies, where it colocalized with HDAC4. As MEF2 has also been implicated in regulation of long-term memory, these data suggest that the repressive effects of HDAC4 on long-term memory may be through interaction with MEF2. In the same genetic background, we also found that RNAi-mediated knockdown of HDAC4 impairs long-term memory, therefore we demonstrate that HDAC4 is not only a repressor of long-term memory, but also modulates normal memory formation." @default.
• W2153274979 created "2016-06-24" @default.
• W2153274979 creator A5000198686 @default.
• W2153274979 creator A5014400549 @default.
• W2153274979 creator A5028222365 @default.
• W2153274979 creator A5066065134 @default.
• W2153274979 date "2013-12-09" @default.
• W2153274979 modified "2023-10-14" @default.
• W2153274979 title "The Histone Deacetylase HDAC4 Regulates Long-Term Memory in Drosophila" @default.
• W2153274979 cites W1565308878 @default.
• W2153274979 cites W1883566698 @default.
• W2153274979 cites W1900565974 @default.
• W2153274979 cites W1912914080 @default.
• W2153274979 cites W1963551704 @default.
• W2153274979 cites W1964574055 @default.
• W2153274979 cites W1966954064 @default.
• W2153274979 cites W1971095698 @default.
• W2153274979 cites W1974223005 @default.
• W2153274979 cites W1976507388 @default.
• W2153274979 cites W1979519622 @default.
• W2153274979 cites W1982766107 @default.
• W2153274979 cites W1987705500 @default.
• W2153274979 cites W1988519721 @default.
• W2153274979 cites W1988694109 @default.
• W2153274979 cites W1992686921 @default.
• W2153274979 cites W1996151441 @default.
• W2153274979 cites W1996507777 @default.
• W2153274979 cites W1998796032 @default.
• W2153274979 cites W2004631364 @default.
• W2153274979 cites W2005414132 @default.
• W2153274979 cites W2006372098 @default.
• W2153274979 cites W2008340135 @default.
• W2153274979 cites W2012083723 @default.
• W2153274979 cites W2013775280 @default.
• W2153274979 cites W2016721540 @default.
• W2153274979 cites W2017092074 @default.
• W2153274979 cites W2019876477 @default.
• W2153274979 cites W2022264926 @default.
• W2153274979 cites W2022814598 @default.
• W2153274979 cites W2023796149 @default.
• W2153274979 cites W2031926951 @default.
• W2153274979 cites W2031954417 @default.
• W2153274979 cites W2040000470 @default.
• W2153274979 cites W2040289150 @default.
• W2153274979 cites W2042966900 @default.
• W2153274979 cites W2043547481 @default.
• W2153274979 cites W2045815014 @default.
• W2153274979 cites W2046244011 @default.
• W2153274979 cites W2046459630 @default.
• W2153274979 cites W2047529879 @default.
• W2153274979 cites W2050541410 @default.
• W2153274979 cites W2051681169 @default.
• W2153274979 cites W2052112605 @default.
• W2153274979 cites W2053591294 @default.
• W2153274979 cites W2056312358 @default.
• W2153274979 cites W2056815371 @default.
• W2153274979 cites W2058815724 @default.
• W2153274979 cites W2064959533 @default.
• W2153274979 cites W2071829685 @default.
• W2153274979 cites W2076669786 @default.
• W2153274979 cites W2076691464 @default.
• W2153274979 cites W2080612159 @default.
• W2153274979 cites W2081092282 @default.
• W2153274979 cites W2090054406 @default.
• W2153274979 cites W2090611194 @default.
• W2153274979 cites W2090760765 @default.
• W2153274979 cites W2100539697 @default.
• W2153274979 cites W2102042356 @default.
• W2153274979 cites W2102884982 @default.
• W2153274979 cites W2105517676 @default.
• W2153274979 cites W2108378823 @default.
• W2153274979 cites W2114539839 @default.
• W2153274979 cites W2120629185 @default.
• W2153274979 cites W2121339588 @default.
• W2153274979 cites W2125601003 @default.
• W2153274979 cites W2129504578 @default.
• W2153274979 cites W2136813339 @default.
• W2153274979 cites W2142388403 @default.
• W2153274979 cites W2146070554 @default.
• W2153274979 cites W2148686253 @default.
• W2153274979 cites W2150681906 @default.
• W2153274979 cites W2152631096 @default.
• W2153274979 cites W2156288001 @default.
• W2153274979 cites W2156613731 @default.
• W2153274979 cites W2158225056 @default.
• W2153274979 cites W4213256327 @default.
• W2153274979 doi "https://doi.org/10.1371/journal.pone.0083903" @default.
• W2153274979 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3857321" @default.
• W2153274979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24349558" @default.
• W2153274979 hasPublicationYear "2013" @default.
• W2153274979 type Work @default.
• W2153274979 sameAs 2153274979 @default.
• W2153274979 citedByCount "67" @default.
• W2153274979 countsByYear W21532749792014 @default.
• W2153274979 countsByYear W21532749792015 @default.
• W2153274979 countsByYear W21532749792016 @default.
• W2153274979 countsByYear W21532749792017 @default.
• W2153274979 countsByYear W21532749792018 @default.

• next