FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153276607> ?p ?o ?g. }

• W2153276607 endingPage "e43913" @default.
• W2153276607 startingPage "e43913" @default.
• W2153276607 abstract "Human African trypanosomiasis or sleeping sickness is a vector-borne parasitic disease that has a major impact on human health and welfare in sub-Saharan countries. Based mostly on data from animal models, it is currently thought that trypanosome entry into the brain occurs by initial infection of the choroid plexus and the circumventricular organs followed days to weeks later by entry into the brain parenchyma. However, Trypanosoma brucei bloodstream forms rapidly cross human brain microvascular endothelial cells in vitro and appear to be able to enter the murine brain without inflicting cerebral injury. Using a murine model and intravital brain imaging, we show that bloodstream forms of T. b. brucei and T. b. rhodesiense enter the brain parenchyma within hours, before a significant level of microvascular inflammation is detectable. Extravascular bloodstream forms were viable as indicated by motility and cell division, and remained detectable for at least 3 days post infection suggesting the potential for parasite survival in the brain parenchyma. Vascular inflammation, as reflected by leukocyte recruitment and emigration from cortical microvessels, became apparent only with increasing parasitemia at later stages of the infection, but was not associated with neurological signs. Extravascular trypanosomes were predominantly associated with postcapillary venules suggesting that early brain infection occurs by parasite passage across the neuroimmunological blood brain barrier. Thus, trypanosomes can invade the murine brain parenchyma during the early stages of the disease before meningoencephalitis is fully established. Whether individual trypanosomes can act alone or require the interaction from a quorum of parasites remains to be shown. The significance of these findings for disease development is now testable." @default.
• W2153276607 created "2016-06-24" @default.
• W2153276607 creator A5028685765 @default.
• W2153276607 creator A5040424012 @default.
• W2153276607 creator A5050854405 @default.
• W2153276607 creator A5050856602 @default.
• W2153276607 creator A5058565390 @default.
• W2153276607 creator A5060017944 @default.
• W2153276607 creator A5076740896 @default.
• W2153276607 creator A5081576868 @default.
• W2153276607 date "2012-08-31" @default.
• W2153276607 modified "2023-10-15" @default.
• W2153276607 title "Early Invasion of Brain Parenchyma by African Trypanosomes" @default.
• W2153276607 cites W139688257 @default.
• W2153276607 cites W1516461966 @default.
• W2153276607 cites W1530987197 @default.
• W2153276607 cites W1560607431 @default.
• W2153276607 cites W1602591430 @default.
• W2153276607 cites W1951558335 @default.
• W2153276607 cites W1965835796 @default.
• W2153276607 cites W1966308941 @default.
• W2153276607 cites W1966399595 @default.
• W2153276607 cites W1967265982 @default.
• W2153276607 cites W1970480941 @default.
• W2153276607 cites W1971235269 @default.
• W2153276607 cites W1976485053 @default.
• W2153276607 cites W1977400775 @default.
• W2153276607 cites W1978320920 @default.
• W2153276607 cites W1980429797 @default.
• W2153276607 cites W1982207977 @default.
• W2153276607 cites W1982617641 @default.
• W2153276607 cites W1983732901 @default.
• W2153276607 cites W1985340062 @default.
• W2153276607 cites W1992758695 @default.
• W2153276607 cites W1993655373 @default.
• W2153276607 cites W1996574563 @default.
• W2153276607 cites W1999475846 @default.
• W2153276607 cites W1999550448 @default.
• W2153276607 cites W2008762173 @default.
• W2153276607 cites W2015318647 @default.
• W2153276607 cites W2015541518 @default.
• W2153276607 cites W2016154498 @default.
• W2153276607 cites W2023100048 @default.
• W2153276607 cites W2024288031 @default.
• W2153276607 cites W2033408027 @default.
• W2153276607 cites W2034995612 @default.
• W2153276607 cites W2036182008 @default.
• W2153276607 cites W2038306142 @default.
• W2153276607 cites W2053329366 @default.
• W2153276607 cites W2053509631 @default.
• W2153276607 cites W2054660283 @default.
• W2153276607 cites W2062359839 @default.
• W2153276607 cites W2064956722 @default.
• W2153276607 cites W2067810471 @default.
• W2153276607 cites W2081842562 @default.
• W2153276607 cites W2082844918 @default.
• W2153276607 cites W2100036957 @default.
• W2153276607 cites W2101099825 @default.
• W2153276607 cites W2102573747 @default.
• W2153276607 cites W2109270284 @default.
• W2153276607 cites W2111096047 @default.
• W2153276607 cites W2111833336 @default.
• W2153276607 cites W2116350092 @default.
• W2153276607 cites W2118970001 @default.
• W2153276607 cites W2120724865 @default.
• W2153276607 cites W2124182727 @default.
• W2153276607 cites W2124196544 @default.
• W2153276607 cites W2127720008 @default.
• W2153276607 cites W2132142558 @default.
• W2153276607 cites W2134248390 @default.
• W2153276607 cites W2134617523 @default.
• W2153276607 cites W2134855562 @default.
• W2153276607 cites W2143094150 @default.
• W2153276607 cites W2145649794 @default.
• W2153276607 cites W2149050443 @default.
• W2153276607 cites W2157236463 @default.
• W2153276607 cites W2165758494 @default.
• W2153276607 cites W2166895048 @default.
• W2153276607 cites W2167541999 @default.
• W2153276607 cites W2322911329 @default.
• W2153276607 cites W2332613468 @default.
• W2153276607 cites W2403469575 @default.
• W2153276607 cites W2405159068 @default.
• W2153276607 cites W2414356196 @default.
• W2153276607 cites W2419519065 @default.
• W2153276607 cites W2471366199 @default.
• W2153276607 cites W2479064699 @default.
• W2153276607 cites W2605645796 @default.
• W2153276607 cites W2885948148 @default.
• W2153276607 cites W2886127856 @default.
• W2153276607 cites W2417766434 @default.
• W2153276607 doi "https://doi.org/10.1371/journal.pone.0043913" @default.
• W2153276607 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3432051" @default.
• W2153276607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22952808" @default.
• W2153276607 hasPublicationYear "2012" @default.
• W2153276607 type Work @default.
• W2153276607 sameAs 2153276607 @default.
• W2153276607 citedByCount "53" @default.

• next