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• W2153286627 startingPage "4627" @default.
• W2153286627 abstract "Memory CD8+ T cells can be divided into two subsets, central memory (T(CM)) and effector memory (T(EM)) CD8+ T cells. We found that CD30, a member of the TNFR-associated factor (TRAF)-linked TNFR superfamily, signaling is involved in differentiation of long-lived CD8+ T(CM) cells following Listeria monocytogenes infection. Although CD8+ T(EM) cells transiently accumulated in the nonlymphoid tissues of CD30 ligand (CD153-/-) mice after infection, long-lived memory CD8+ T(CM) cells were poorly generated in these mice. CCR7 mRNA expression was down-regulated in CD8+ T cells of the spleen of CD153-/- mice in vivo and the expression was up-regulated in CD8+ T(EM) cells by anti-CD30 mAb cross-linking in vitro. These results suggest that CD30/CD30 ligand signaling plays an important role in the generation of long-lived memory CD8+ T cells at least partly by triggering homing receptors for T(CM) cells." @default.
• W2153286627 created "2016-06-24" @default.
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• W2153286627 date "2005-10-01" @default.
• W2153286627 modified "2023-09-28" @default.
• W2153286627 title "A Novel Role of CD30/CD30 Ligand Signaling in the Generation of Long-Lived Memory CD8+ T Cells" @default.
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• W2153286627 doi "https://doi.org/10.4049/jimmunol.175.7.4627" @default.
• W2153286627 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16177108" @default.
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