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- W2153295816 abstract "Background : Prolonged corrected QT interval (QTc) holds independent prognostic importancein predicting mortality in patients with coronary artery disease, diabetes mellitus andcongestive heart failure. However, its association with all cause or cardiac mortality in thegeneral population remains unclear. We evaluated the relationship between prolonged QTcand total mortality among patients with syncope. Methods : This was a retrospective study of 348 patients presenting to the emergency departmentwith syncope of any etiology over a period of one year. All patients with atrial fibrillation,left bundle branch block and cardiac devices (pacemaker/defibrillator) were excluded. ProlongedQTc interval was defined as QTc interval ≥ 440 ms. The primary end point for thisstudy was total mortality in patients presenting with syncope. Results : There were 58 (16%) deaths in this population during a mean follow-up of 30 months.Patients with prolonged QTc interval had significantly higher mortality when compared tothose with normal QTc interval (22% vs 11%; p = 0.004). This significance was not retainedafter adjustment for covariates in the Cox regression model, where we found that age ≥ 65 years(hazard ratio [HR] 7.9; 95% confidence interval [CI] 1.9–32.9; p = 0.004) and QTc interval≥ 500 ms (HR 3.5; 95% CI 1.56–8.12; p = 0.002) were predictors of increased mortalityamong patients with syncope. Conclusions : In elderly patients presenting to the emergency department with syncope, QTcinterval ≥ 500 ms helps identify patients at higher risk of adverse outcomes. (Cardiol J 2011;18, 4: 395–400)" @default.
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- W2153295816 date "2011-01-01" @default.
- W2153295816 modified "2023-09-23" @default.
- W2153295816 title "Corrected QT interval as a predictor of mortality in elderly patients with syncope." @default.
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