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• W2153336804 abstract "Characterizing the functions of the many genes discovered by the sequencing projects is now the primary focus of genome-scale studies. Although sequence or structure-based comparisons are helping to generate hypotheses on the biochemical functions of many gene products, determining the in vivo role(s) for large sets of genes remains a critical objective. RNA interference (RNAi) offers a rapid way to gain a first look at loss-of-function phenotypes associated with specific genes. So far RNAi has been used to test the function of a third of the predicted genes in the Caenorhabditis elegans (C. elegans) genome, and it can be expected that a first pass survey of the entire genome will soon be completed. From the current body of work an initial estimate of the power and challenges of using RNAi for genome-wide analyses can be made. A comparison of results obtained from independent large-scale RNAi studies reveals that despite a high degree of congruence, no single study is likely to achieve a comprehensive RNAi-based phenotypic map of the C. elegans genome; instead a more accurate picture will be assembled from a composite of independent results for the same genes. RNAi analysis, together with other functional genomic approaches such as expression profiling and protein interaction mapping, is transforming C. elegans into a premier model system for the development and integration of functional genomic approaches in a metazoan." @default.
• W2153336804 created "2016-06-24" @default.
• W2153336804 creator A5028363830 @default.
• W2153336804 creator A5077305797 @default.
• W2153336804 date "2002-04-01" @default.
• W2153336804 modified "2023-09-25" @default.
• W2153336804 title "RNAi-Based Functional Genomics in Caenorhabditis elegans" @default.
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• W2153336804 doi "https://doi.org/10.2174/1389202024605224" @default.
• W2153336804 hasPublicationYear "2002" @default.
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