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- W2153338081 abstract "The hypoxic environment imposes severe selective pressure on species living at high altitude. To understand the genetic bases of adaptation to high altitude in dogs, we performed whole-genome sequencing of 60 dogs including five breeds living at continuous altitudes along the Tibetan Plateau from 800 to 5100 m as well as one European breed. More than 150× sequencing coverage for each breed provides us with a comprehensive assessment of the genetic polymorphisms of the dogs, including Tibetan Mastiffs. Comparison of the breeds from different altitudes reveals strong signals of population differentiation at the locus of hypoxia-related genes including endothelial Per-Arnt-Sim (PAS) domain protein 1 ( EPAS1 ) and beta hemoglobin cluster. Notably, four novel nonsynonymous mutations specific to high-altitude dogs are identified at EPAS1 , one of which occurred at a quite conserved site in the PAS domain. The association testing between EPAS1 genotypes and blood-related phenotypes on additional high-altitude dogs reveals that the homozygous mutation is associated with decreased blood flow resistance, which may help to improve hemorheologic fitness. Interestingly, EPAS1 was also identified as a selective target in Tibetan highlanders, though no amino acid changes were found. Thus, our results not only indicate parallel evolution of humans and dogs in adaptation to high-altitude hypoxia, but also provide a new opportunity to study the role of EPAS1 in the adaptive processes." @default.
- W2153338081 created "2016-06-24" @default.
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- W2153338081 date "2014-04-10" @default.
- W2153338081 modified "2023-10-18" @default.
- W2153338081 title "Whole-genome sequencing of six dog breeds from continuous altitudes reveals adaptation to high-altitude hypoxia" @default.
- W2153338081 cites W1968642517 @default.
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- W2153338081 cites W1980608095 @default.
- W2153338081 cites W1980740976 @default.
- W2153338081 cites W1984068087 @default.
- W2153338081 cites W1985006546 @default.
- W2153338081 cites W2001091293 @default.
- W2153338081 cites W2007313193 @default.
- W2153338081 cites W2010389102 @default.
- W2153338081 cites W2025253353 @default.
- W2153338081 cites W2028331311 @default.
- W2153338081 cites W2033151532 @default.
- W2153338081 cites W2037312364 @default.
- W2153338081 cites W2042264086 @default.
- W2153338081 cites W2044382903 @default.
- W2153338081 cites W2047366062 @default.
- W2153338081 cites W2057998085 @default.
- W2153338081 cites W2060346932 @default.
- W2153338081 cites W2062818316 @default.
- W2153338081 cites W2068835839 @default.
- W2153338081 cites W2070261550 @default.
- W2153338081 cites W2075183916 @default.
- W2153338081 cites W2075292410 @default.
- W2153338081 cites W2078074521 @default.
- W2153338081 cites W2086913408 @default.
- W2153338081 cites W2091983142 @default.
- W2153338081 cites W2092574926 @default.
- W2153338081 cites W2096420865 @default.
- W2153338081 cites W2098460741 @default.
- W2153338081 cites W2102185362 @default.
- W2153338081 cites W2102860523 @default.
- W2153338081 cites W2103337472 @default.
- W2153338081 cites W2103441770 @default.
- W2153338081 cites W2105799757 @default.
- W2153338081 cites W2108234281 @default.
- W2153338081 cites W2109099152 @default.
- W2153338081 cites W2115837368 @default.
- W2153338081 cites W2116668053 @default.
- W2153338081 cites W2120772351 @default.
- W2153338081 cites W2121512231 @default.
- W2153338081 cites W2122603731 @default.
- W2153338081 cites W2126193663 @default.
- W2153338081 cites W2130234063 @default.
- W2153338081 cites W2132632499 @default.
- W2153338081 cites W2134440374 @default.
- W2153338081 cites W2137015675 @default.
- W2153338081 cites W2138655328 @default.
- W2153338081 cites W2139752884 @default.
- W2153338081 cites W2147575903 @default.
- W2153338081 cites W2148830024 @default.
- W2153338081 cites W2149716668 @default.
- W2153338081 cites W2149992227 @default.
- W2153338081 cites W2150131459 @default.
- W2153338081 cites W2150536115 @default.
- W2153338081 cites W2150934173 @default.
- W2153338081 cites W2151242378 @default.
- W2153338081 cites W2154096947 @default.