FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153340528> ?p ?o ?g. }

• W2153340528 endingPage "111" @default.
• W2153340528 startingPage "87" @default.
• W2153340528 abstract "There is good evidence indicating that ion-transport pathways in the apical regions of lingual epithelial cells, including taste bud cells, may play a role in salt taste reception. In this article, we present evidence that, in the case of the dog, there also exists a sugar-activated ion-transport pathway that is linked to sugar taste transduction. Evidence was drawn from two parallel lines of experiments: (a) ion-transport studies on the isolated canine lingual epithelium, and (b) recordings from the canine chorda tympani. The results in vitro showed that both mono- and disaccharides in the mucosal bath stimulate a dose-dependent increase in the short-circuit current over the concentration range coincident with mammalian sugar taste responses. Transepithelial current evoked by glucose, fructose, or sucrose in either 30 mM NaCl or in Krebs-Henseleit buffer (K-H) was partially blocked by amiloride. Among current carriers activated by saccharides, the current response was greater with Na than with K. Ion flux measurements in K-H during stimulation with 3-O-methylglucose showed that the sugar-evoked current was due to an increase in the Na influx. Ouabain or amiloride reduced the sugar-evoked Na influx without effect on sugar transport as measured with tritiated 3-O-methylglucose. Amiloride inhibited the canine chorda tympani response to 0.5 M NaCl by 70-80% and the response to 0.5 M KCl by approximately 40%. This agreed with the percent inhibition by amiloride of the short-circuit current supported in vitro by NaCl and KCl. Amiloride also partially inhibited the chorda tympani responses to sucrose and to fructose. The results indicate that in the dog: (a) the ion transporter subserving Na taste also subserves part of the response to K, and (b) a sugar-activated, Na-preferring ion-transport system is one mechanism mediating sugar taste transduction. Results in the literature indicate a similar sweet taste mechanism for humans." @default.
• W2153340528 created "2016-06-24" @default.
• W2153340528 creator A5008130311 @default.
• W2153340528 creator A5017468042 @default.
• W2153340528 creator A5025008584 @default.
• W2153340528 creator A5075266077 @default.
• W2153340528 date "1988-07-01" @default.
• W2153340528 modified "2023-10-17" @default.
• W2153340528 title "Sugar-activated ion transport in canine lingual epithelium. Implications for sugar taste transduction." @default.
• W2153340528 cites W1519816733 @default.
• W2153340528 cites W1540796239 @default.
• W2153340528 cites W1964163394 @default.
• W2153340528 cites W1988414681 @default.
• W2153340528 cites W1990768783 @default.
• W2153340528 cites W1995530855 @default.
• W2153340528 cites W1995610534 @default.
• W2153340528 cites W1997542673 @default.
• W2153340528 cites W2001906697 @default.
• W2153340528 cites W2002073252 @default.
• W2153340528 cites W2022750756 @default.
• W2153340528 cites W2024881871 @default.
• W2153340528 cites W2029473565 @default.
• W2153340528 cites W2034015328 @default.
• W2153340528 cites W2037745320 @default.
• W2153340528 cites W2041329572 @default.
• W2153340528 cites W2062110180 @default.
• W2153340528 cites W2066094532 @default.
• W2153340528 cites W2067006970 @default.
• W2153340528 cites W2067105358 @default.
• W2153340528 cites W2071689264 @default.
• W2153340528 cites W2072007942 @default.
• W2153340528 cites W2091761874 @default.
• W2153340528 cites W2093118564 @default.
• W2153340528 cites W2094323420 @default.
• W2153340528 cites W2099470291 @default.
• W2153340528 cites W2129655744 @default.
• W2153340528 cites W2132156293 @default.
• W2153340528 cites W2137431663 @default.
• W2153340528 cites W2159898313 @default.
• W2153340528 cites W2163394937 @default.
• W2153340528 cites W2287977632 @default.
• W2153340528 cites W2395729968 @default.
• W2153340528 cites W2401677273 @default.
• W2153340528 cites W2418809980 @default.
• W2153340528 cites W2422064898 @default.
• W2153340528 cites W2474522450 @default.
• W2153340528 cites W2481287682 @default.
• W2153340528 doi "https://doi.org/10.1085/jgp.92.1.87" @default.
• W2153340528 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2228888" @default.
• W2153340528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3171536" @default.
• W2153340528 hasPublicationYear "1988" @default.
• W2153340528 type Work @default.
• W2153340528 sameAs 2153340528 @default.
• W2153340528 citedByCount "70" @default.
• W2153340528 countsByYear W21533405282016 @default.
• W2153340528 countsByYear W21533405282020 @default.
• W2153340528 crossrefType "journal-article" @default.
• W2153340528 hasAuthorship W2153340528A5008130311 @default.
• W2153340528 hasAuthorship W2153340528A5017468042 @default.
• W2153340528 hasAuthorship W2153340528A5025008584 @default.
• W2153340528 hasAuthorship W2153340528A5075266077 @default.
• W2153340528 hasBestOaLocation W21533405281 @default.
• W2153340528 hasConcept C12554922 @default.
• W2153340528 hasConcept C126322002 @default.
• W2153340528 hasConcept C134018914 @default.
• W2153340528 hasConcept C15152581 @default.
• W2153340528 hasConcept C178790620 @default.
• W2153340528 hasConcept C185592680 @default.
• W2153340528 hasConcept C2775871351 @default.
• W2153340528 hasConcept C2776970464 @default.
• W2153340528 hasConcept C2777108408 @default.
• W2153340528 hasConcept C2777687625 @default.
• W2153340528 hasConcept C2778597767 @default.
• W2153340528 hasConcept C2779133857 @default.
• W2153340528 hasConcept C2779608910 @default.
• W2153340528 hasConcept C41625074 @default.
• W2153340528 hasConcept C529295009 @default.
• W2153340528 hasConcept C537181965 @default.
• W2153340528 hasConcept C54355233 @default.
• W2153340528 hasConcept C55493867 @default.
• W2153340528 hasConcept C71924100 @default.
• W2153340528 hasConcept C86803240 @default.
• W2153340528 hasConcept C8868529 @default.
• W2153340528 hasConcept C99975950 @default.
• W2153340528 hasConceptScore W2153340528C12554922 @default.
• W2153340528 hasConceptScore W2153340528C126322002 @default.
• W2153340528 hasConceptScore W2153340528C134018914 @default.
• W2153340528 hasConceptScore W2153340528C15152581 @default.
• W2153340528 hasConceptScore W2153340528C178790620 @default.
• W2153340528 hasConceptScore W2153340528C185592680 @default.
• W2153340528 hasConceptScore W2153340528C2775871351 @default.
• W2153340528 hasConceptScore W2153340528C2776970464 @default.
• W2153340528 hasConceptScore W2153340528C2777108408 @default.
• W2153340528 hasConceptScore W2153340528C2777687625 @default.
• W2153340528 hasConceptScore W2153340528C2778597767 @default.
• W2153340528 hasConceptScore W2153340528C2779133857 @default.
• W2153340528 hasConceptScore W2153340528C2779608910 @default.
• W2153340528 hasConceptScore W2153340528C41625074 @default.

• next