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- W2153341565 abstract "The sodium-activated potassium KNa channels Slack and Slick are encoded by KCNT1 and KCNT2, respectively. These channels are found in neurons throughout the brain, and are responsible for a delayed outward current termed IKNa. These currents integrate into shaping neuronal excitability, as well as adaptation in response to maintained stimulation. Abnormal Slack channel activity may play a role in Fragile X syndrome, the most common cause for intellectual disability and inherited autism. Slack channels interact directly with the Fragile X Mental Retardation protein (FMRP) and IKNa is reduced in animal models of Fragile X syndrome that lack FMRP. Human Slack mutations that alter channel activity can also lead to intellectual disability, as has been found for several childhood epileptic disorders. Ongoing research is elucidating the relationship between mutant Slack channel activity, development of early onset epilepsies and intellectual impairment. This review describes the emerging role of Slack channels in intellectual disability, coupled with an overview of the physiological role of neuronal IKNa currents." @default.
- W2153341565 created "2016-06-24" @default.
- W2153341565 creator A5036389887 @default.
- W2153341565 creator A5053610259 @default.
- W2153341565 date "2014-07-28" @default.
- W2153341565 modified "2023-10-17" @default.
- W2153341565 title "Emerging role of the KCNT1 Slack channel in intellectual disability" @default.
- W2153341565 cites W1480513449 @default.
- W2153341565 cites W1492127714 @default.
- W2153341565 cites W1494010743 @default.
- W2153341565 cites W1500569882 @default.
- W2153341565 cites W1510757466 @default.
- W2153341565 cites W1556161696 @default.
- W2153341565 cites W1566518481 @default.
- W2153341565 cites W1599319686 @default.
- W2153341565 cites W1749057191 @default.
- W2153341565 cites W1827142872 @default.
- W2153341565 cites W1877319790 @default.
- W2153341565 cites W1908661569 @default.
- W2153341565 cites W1965427013 @default.
- W2153341565 cites W1966934847 @default.
- W2153341565 cites W1967983600 @default.
- W2153341565 cites W1968418618 @default.
- W2153341565 cites W1968608231 @default.
- W2153341565 cites W1970264142 @default.
- W2153341565 cites W1976482700 @default.
- W2153341565 cites W1976962789 @default.
- W2153341565 cites W1978538275 @default.
- W2153341565 cites W1979037838 @default.
- W2153341565 cites W1979614243 @default.
- W2153341565 cites W1980805930 @default.
- W2153341565 cites W1982177213 @default.
- W2153341565 cites W1982728552 @default.
- W2153341565 cites W1984189293 @default.
- W2153341565 cites W1984938584 @default.
- W2153341565 cites W1984991691 @default.
- W2153341565 cites W1988595550 @default.
- W2153341565 cites W1989029077 @default.
- W2153341565 cites W1990929336 @default.
- W2153341565 cites W1991063399 @default.
- W2153341565 cites W1993780110 @default.
- W2153341565 cites W1993938009 @default.
- W2153341565 cites W1994898191 @default.
- W2153341565 cites W1995658722 @default.
- W2153341565 cites W1997765371 @default.
- W2153341565 cites W1999513543 @default.
- W2153341565 cites W2000054304 @default.
- W2153341565 cites W2000130976 @default.
- W2153341565 cites W2001465365 @default.
- W2153341565 cites W2002600603 @default.
- W2153341565 cites W2002780348 @default.
- W2153341565 cites W2006053579 @default.
- W2153341565 cites W2007372862 @default.
- W2153341565 cites W2007860569 @default.
- W2153341565 cites W2010157600 @default.
- W2153341565 cites W2010492400 @default.
- W2153341565 cites W2013080889 @default.
- W2153341565 cites W2017361992 @default.
- W2153341565 cites W2019931248 @default.
- W2153341565 cites W2021890154 @default.
- W2153341565 cites W2022347217 @default.
- W2153341565 cites W2028511100 @default.
- W2153341565 cites W2029965714 @default.
- W2153341565 cites W2033814322 @default.
- W2153341565 cites W2034651748 @default.
- W2153341565 cites W2035598121 @default.
- W2153341565 cites W2036319351 @default.
- W2153341565 cites W2037174026 @default.
- W2153341565 cites W2038561863 @default.
- W2153341565 cites W2042728043 @default.
- W2153341565 cites W2043162533 @default.
- W2153341565 cites W2043364106 @default.
- W2153341565 cites W2043525076 @default.
- W2153341565 cites W2049676741 @default.
- W2153341565 cites W2050643127 @default.
- W2153341565 cites W2053989438 @default.
- W2153341565 cites W2054091111 @default.
- W2153341565 cites W2056649843 @default.
- W2153341565 cites W2057924235 @default.
- W2153341565 cites W2062463079 @default.
- W2153341565 cites W2062477559 @default.
- W2153341565 cites W2064474429 @default.
- W2153341565 cites W2065117619 @default.
- W2153341565 cites W2067008379 @default.
- W2153341565 cites W2068841959 @default.
- W2153341565 cites W2071250933 @default.
- W2153341565 cites W2073032316 @default.
- W2153341565 cites W2074967116 @default.
- W2153341565 cites W2079864604 @default.
- W2153341565 cites W2080287250 @default.
- W2153341565 cites W2081119737 @default.
- W2153341565 cites W2081880339 @default.
- W2153341565 cites W2083819018 @default.
- W2153341565 cites W2085408699 @default.
- W2153341565 cites W2085488786 @default.
- W2153341565 cites W2089201761 @default.
- W2153341565 cites W2090023121 @default.
- W2153341565 cites W2090518754 @default.
- W2153341565 cites W2092726215 @default.
- W2153341565 cites W2094359469 @default.