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- W2153342976 abstract "Plasmacytoid dendritic cells (pDC) exert contradictory roles: they represent major players in the pathogenesis of type I interferon-mediated autoimmunity but contribute to tolerance in the transplant setting. In this study we describe pDC as cellular enhancers of B cell-derived IL-10 production, a mechanism recently described as relevant in maintaining peripheral tolerance. Our data demonstrate that in human peripheral blood pDC augment IL-10 production in B cells in response to TLR7 and -9 ligands. They further show that pDC themselves produce IL-10 in response to TLR stimulation, most prominently after triggering of TLR7. Additionally, the data indicate that the positive regulatory effect of pDC on IL-10 production is not due to type I interferon production or other soluble factors. We conclude that pDC/B cell contact is essential for B cell-mediated immune suppression." @default.
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- W2153342976 date "2012-09-17" @default.
- W2153342976 modified "2023-10-16" @default.
- W2153342976 title "Plasmacytoid dendritic cells control B cell-derived IL-10 production" @default.
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- W2153342976 doi "https://doi.org/10.3109/08916934.2012.719955" @default.
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