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- W2153360765 abstract "Introduction Past research has reported that single nucleotide polymorphisms (SNPs) in fatty acid desaturase 1 and 2 (FADS1/2) can influence plasma fatty acid (FA) profiles. Changes in FA profiles are known to influence inflammatory processes; therefore both FA and SNPs in FADS1/2 may affect inflammation. The goals of this study were to (i) examine the relationships between individual n−6 FA and estimates of FA desaturation with circulating high sensitivity C-reactive protein (hsCRP) levels, and (ii) determine whether SNPs in FADS1/2 are associated with changes in hsCRP. Methods FA and hsCRP were measured in fasted plasma samples from 878 healthy young adults (20–29 yrs). Circulating levels of plasma linoleic (LA), γ-linolenic (GLA), dihomo-γ-linolenic (DGLA) and arachidonic (AA) acids were measured by gas chromatography and used to calculate desaturase indices for FADS1/2. Nineteen SNPs in FADS1/2 were genotyped in all subjects and six (rs174579, rs174593, rs174626, rs526126, rs968567 and rs17831757) were further analyzed. Results Significant inverse associations were found between LA and hsCRP (p=8.55×10−9) and the FADS1 desaturase index and hsCRP (p=4.41×10−6). A significant positive association was found between DGLA and hsCRP (p=9.10×10−11). Several SNPs were associated with circulating levels of individual FA and desaturase indices, with minor allele carriers having lower AA levels and reduced desaturase indices. A single SNP in FADS2 (rs526126) was weakly associated with hsCRP (p=0.05). Conclusions This study highlights the relationships between FA and hsCRP, and confirms that FA are strongly influenced by SNPs in FADS1/2. Furthermore, we found weak evidence that SNPs in FADS1/2 may influence hsCRP levels in young adults." @default.
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- W2153360765 date "2013-09-01" @default.
- W2153360765 modified "2023-09-27" @default.
- W2153360765 title "Variation in the FADS1/2 gene cluster alters plasma n−6 PUFA and is weakly associated with hsCRP levels in healthy young adults" @default.
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- W2153360765 cites W1978929392 @default.
- W2153360765 cites W1983519516 @default.
- W2153360765 cites W1992677117 @default.
- W2153360765 cites W1997080081 @default.
- W2153360765 cites W1998076000 @default.
- W2153360765 cites W2000142207 @default.
- W2153360765 cites W2003784331 @default.
- W2153360765 cites W2018423751 @default.
- W2153360765 cites W2021904947 @default.
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- W2153360765 cites W2039127164 @default.
- W2153360765 cites W2044868796 @default.
- W2153360765 cites W2050574530 @default.
- W2153360765 cites W2053442712 @default.
- W2153360765 cites W2059751934 @default.
- W2153360765 cites W2061658502 @default.
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- W2153360765 cites W2078112038 @default.
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- W2153360765 doi "https://doi.org/10.1016/j.plefa.2013.06.003" @default.
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