Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153363068> ?p ?o ?g. }
- W2153363068 endingPage "e24565" @default.
- W2153363068 startingPage "e24565" @default.
- W2153363068 abstract "A limitation in the uptake of many drugs is the restricted permeation through tissue barriers. There are two general ways to cross barriers formed by cell layers: by transcytosis or by diffusion through the intercellular space. In the latter, tight junctions (TJs) play the decisive role in the regulation of the barrier permeability. Thus, transient modulation of TJs is a potent strategy to improve drug delivery. There have been extensive studies on surfactant-like absorption enhancers. One of the most effective enhancers found is sodium caprate. However, this modulates TJs in an unspecific fashion. A novel approach would be the specific modulation of TJ-associated marvel proteins and claudins, which are the main structural components of the TJs. Recent studies have identified synthetic peptidomimetics and RNA interference techniques to downregulate the expression of targeted TJ proteins. This review summarizes current progress and discusses the impact on TJs' barrier function." @default.
- W2153363068 created "2016-06-24" @default.
- W2153363068 creator A5014635486 @default.
- W2153363068 creator A5055523748 @default.
- W2153363068 creator A5074658182 @default.
- W2153363068 date "2013-04-01" @default.
- W2153363068 modified "2023-09-24" @default.
- W2153363068 title "Trends in drug delivery through tissue barriers containing tight junctions" @default.
- W2153363068 cites W134089957 @default.
- W2153363068 cites W1504811282 @default.
- W2153363068 cites W1523737655 @default.
- W2153363068 cites W1561225333 @default.
- W2153363068 cites W1966184698 @default.
- W2153363068 cites W1966478560 @default.
- W2153363068 cites W1968744970 @default.
- W2153363068 cites W1968898370 @default.
- W2153363068 cites W1969012119 @default.
- W2153363068 cites W1975663730 @default.
- W2153363068 cites W1976116333 @default.
- W2153363068 cites W1989070672 @default.
- W2153363068 cites W1991404976 @default.
- W2153363068 cites W1992007939 @default.
- W2153363068 cites W1993033152 @default.
- W2153363068 cites W1994125288 @default.
- W2153363068 cites W1995942491 @default.
- W2153363068 cites W2002113298 @default.
- W2153363068 cites W2002451924 @default.
- W2153363068 cites W2003445994 @default.
- W2153363068 cites W2005811307 @default.
- W2153363068 cites W2008908364 @default.
- W2153363068 cites W2011356699 @default.
- W2153363068 cites W2012640716 @default.
- W2153363068 cites W2017497221 @default.
- W2153363068 cites W2023041059 @default.
- W2153363068 cites W2024005495 @default.
- W2153363068 cites W2024961459 @default.
- W2153363068 cites W2025592916 @default.
- W2153363068 cites W2026696520 @default.
- W2153363068 cites W2031305612 @default.
- W2153363068 cites W2034014716 @default.
- W2153363068 cites W2035009843 @default.
- W2153363068 cites W2035998324 @default.
- W2153363068 cites W2037479315 @default.
- W2153363068 cites W2037931437 @default.
- W2153363068 cites W2038390726 @default.
- W2153363068 cites W2038979660 @default.
- W2153363068 cites W2043067003 @default.
- W2153363068 cites W2043475722 @default.
- W2153363068 cites W2047388788 @default.
- W2153363068 cites W2048168357 @default.
- W2153363068 cites W2049278300 @default.
- W2153363068 cites W2050525037 @default.
- W2153363068 cites W2050568092 @default.
- W2153363068 cites W2052157194 @default.
- W2153363068 cites W2054478082 @default.
- W2153363068 cites W2056169693 @default.
- W2153363068 cites W2057883890 @default.
- W2153363068 cites W2061955387 @default.
- W2153363068 cites W2064592409 @default.
- W2153363068 cites W2065422003 @default.
- W2153363068 cites W2072108209 @default.
- W2153363068 cites W2072564570 @default.
- W2153363068 cites W2074505343 @default.
- W2153363068 cites W2077284777 @default.
- W2153363068 cites W2079482620 @default.
- W2153363068 cites W2081661358 @default.
- W2153363068 cites W2082609680 @default.
- W2153363068 cites W2087240145 @default.
- W2153363068 cites W2088163593 @default.
- W2153363068 cites W2088821423 @default.
- W2153363068 cites W2091118116 @default.
- W2153363068 cites W2098678505 @default.
- W2153363068 cites W2101099825 @default.
- W2153363068 cites W2103617291 @default.
- W2153363068 cites W2103729492 @default.
- W2153363068 cites W2103831817 @default.
- W2153363068 cites W2104567497 @default.
- W2153363068 cites W2107336169 @default.
- W2153363068 cites W2110656546 @default.
- W2153363068 cites W2114135018 @default.
- W2153363068 cites W2116901311 @default.
- W2153363068 cites W2116946576 @default.
- W2153363068 cites W2120914031 @default.
- W2153363068 cites W2123230988 @default.
- W2153363068 cites W2126588819 @default.
- W2153363068 cites W2129983297 @default.
- W2153363068 cites W2131543145 @default.
- W2153363068 cites W2134716171 @default.
- W2153363068 cites W2136491609 @default.
- W2153363068 cites W2140839091 @default.
- W2153363068 cites W2141641239 @default.
- W2153363068 cites W2143626075 @default.
- W2153363068 cites W2144272339 @default.
- W2153363068 cites W2145518630 @default.
- W2153363068 cites W2147810729 @default.
- W2153363068 cites W2147977611 @default.
- W2153363068 cites W2149037769 @default.
- W2153363068 cites W2150066013 @default.