FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153391036> ?p ?o ?g. }

• W2153391036 endingPage "110" @default.
• W2153391036 startingPage "105" @default.
• W2153391036 abstract "The role of T-type Ca 2+ channels for cardiovascular physiology, in particular blood pressure regulation, is controversial. Selective blockade of T-type Ca 2+ channels in resistance arteries has been proposed to explain the effect of the antihypertensive drug mibefradil. In the present study, we used a third generation, time- and tissue-specific conditional knockout model of the L-type Ca 2+ channel Ca v 1.2 (Ca v 1.2 SMAKO mice) to genetically dissect the effects of mibefradil on T- and L-type Ca 2+ channels. Myogenic tone and phenylephrine-induced contraction in hindlimb perfusion experiments were sensitive to mibefradil in control mice, whereas the drug showed no effect in Ca v 1.2-deficient animals. Mean arterial blood pressure in awake, freely moving control mice was reduced by 38±2.5 mm Hg at a dose of 1.25 mg/kg bodyweight mibefradil, but not changed in Ca v 1.2 SMAKO mice. These results demonstrate that the effect of the putative T-type Ca 2+ channel-selective blocker mibefradil on blood pressure and small vessel myogenic tone is mediated by the Ca v 1.2 L-type Ca 2+ channel." @default.
• W2153391036 created "2016-06-24" @default.
• W2153391036 creator A5000119677 @default.
• W2153391036 creator A5046516279 @default.
• W2153391036 creator A5056472274 @default.
• W2153391036 creator A5059973447 @default.
• W2153391036 creator A5091874127 @default.
• W2153391036 date "2006-01-06" @default.
• W2153391036 modified "2023-10-14" @default.
• W2153391036 title "Antihypertensive Effects of the Putative T-Type Calcium Channel Antagonist Mibefradil Are Mediated by the L-Type Calcium Channel Ca _v 1.2" @default.
• W2153391036 cites W154975620 @default.
• W2153391036 cites W1579034755 @default.
• W2153391036 cites W1976722240 @default.
• W2153391036 cites W1978673213 @default.
• W2153391036 cites W1980975971 @default.
• W2153391036 cites W2007232456 @default.
• W2153391036 cites W2025175696 @default.
• W2153391036 cites W2038470044 @default.
• W2153391036 cites W2041360032 @default.
• W2153391036 cites W2048844546 @default.
• W2153391036 cites W2075878571 @default.
• W2153391036 cites W2078659551 @default.
• W2153391036 cites W2087408563 @default.
• W2153391036 cites W2110993458 @default.
• W2153391036 cites W2112520390 @default.
• W2153391036 cites W2116129188 @default.
• W2153391036 cites W2125632358 @default.
• W2153391036 cites W2126046035 @default.
• W2153391036 cites W2136358674 @default.
• W2153391036 cites W2171830917 @default.
• W2153391036 cites W2333316503 @default.
• W2153391036 doi "https://doi.org/10.1161/01.res.0000197851.11031.9c" @default.
• W2153391036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16306443" @default.
• W2153391036 hasPublicationYear "2006" @default.
• W2153391036 type Work @default.
• W2153391036 sameAs 2153391036 @default.
• W2153391036 citedByCount "68" @default.
• W2153391036 countsByYear W21533910362012 @default.
• W2153391036 countsByYear W21533910362013 @default.
• W2153391036 countsByYear W21533910362014 @default.
• W2153391036 countsByYear W21533910362015 @default.
• W2153391036 countsByYear W21533910362016 @default.
• W2153391036 countsByYear W21533910362017 @default.
• W2153391036 countsByYear W21533910362020 @default.
• W2153391036 countsByYear W21533910362021 @default.
• W2153391036 countsByYear W21533910362022 @default.
• W2153391036 crossrefType "journal-article" @default.
• W2153391036 hasAuthorship W2153391036A5000119677 @default.
• W2153391036 hasAuthorship W2153391036A5046516279 @default.
• W2153391036 hasAuthorship W2153391036A5056472274 @default.
• W2153391036 hasAuthorship W2153391036A5059973447 @default.
• W2153391036 hasAuthorship W2153391036A5091874127 @default.
• W2153391036 hasBestOaLocation W21533910361 @default.
• W2153391036 hasConcept C117499352 @default.
• W2153391036 hasConcept C126322002 @default.
• W2153391036 hasConcept C134018914 @default.
• W2153391036 hasConcept C153461711 @default.
• W2153391036 hasConcept C185592680 @default.
• W2153391036 hasConcept C18699975 @default.
• W2153391036 hasConcept C2777952589 @default.
• W2153391036 hasConcept C2778673320 @default.
• W2153391036 hasConcept C2780356492 @default.
• W2153391036 hasConcept C30979828 @default.
• W2153391036 hasConcept C519063684 @default.
• W2153391036 hasConcept C71924100 @default.
• W2153391036 hasConcept C84393581 @default.
• W2153391036 hasConcept C85520022 @default.
• W2153391036 hasConcept C98274493 @default.
• W2153391036 hasConceptScore W2153391036C117499352 @default.
• W2153391036 hasConceptScore W2153391036C126322002 @default.
• W2153391036 hasConceptScore W2153391036C134018914 @default.
• W2153391036 hasConceptScore W2153391036C153461711 @default.
• W2153391036 hasConceptScore W2153391036C185592680 @default.
• W2153391036 hasConceptScore W2153391036C18699975 @default.
• W2153391036 hasConceptScore W2153391036C2777952589 @default.
• W2153391036 hasConceptScore W2153391036C2778673320 @default.
• W2153391036 hasConceptScore W2153391036C2780356492 @default.
• W2153391036 hasConceptScore W2153391036C30979828 @default.
• W2153391036 hasConceptScore W2153391036C519063684 @default.
• W2153391036 hasConceptScore W2153391036C71924100 @default.
• W2153391036 hasConceptScore W2153391036C84393581 @default.
• W2153391036 hasConceptScore W2153391036C85520022 @default.
• W2153391036 hasConceptScore W2153391036C98274493 @default.
• W2153391036 hasIssue "1" @default.
• W2153391036 hasLocation W21533910361 @default.
• W2153391036 hasLocation W21533910362 @default.
• W2153391036 hasOpenAccess W2153391036 @default.
• W2153391036 hasPrimaryLocation W21533910361 @default.
• W2153391036 hasRelatedWork W1983744845 @default.
• W2153391036 hasRelatedWork W1988272578 @default.
• W2153391036 hasRelatedWork W2033792938 @default.
• W2153391036 hasRelatedWork W2044873616 @default.
• W2153391036 hasRelatedWork W2078205120 @default.
• W2153391036 hasRelatedWork W2153391036 @default.
• W2153391036 hasRelatedWork W2232437174 @default.
• W2153391036 hasRelatedWork W2256871308 @default.
• W2153391036 hasRelatedWork W2309136548 @default.
• W2153391036 hasRelatedWork W2886113429 @default.

• next