Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153397369> ?p ?o ?g. }
- W2153397369 endingPage "149" @default.
- W2153397369 startingPage "141" @default.
- W2153397369 abstract "Pemetrexed, a new cytotoxic agent, is a potent inhibitor of thymidylate synthase and other folate-dependent enzymes. Firstly, pemetrexed was approved in combination with cisplatin for the treatment of malignant pleural mesothelioma. Successively, it has been studied, as single-agent, in phase II and III trials for second-line therapy of non-small cell lung cancer (NSCLC). Based on these results, pemetrexed has been registered for the treatment of recurrent NSCLC. The next step was to test pemetrexed plus cisplatin versus gemcitabine plus cisplatin, as first-line therapy in advanced NSCLC patients, in a phase III, non-inferiority, randomized trial. This trial reported the pemetrexed plus cisplatin regimen to be not inferior, in terms of activity and efficacy, to the control arm but statistically better tolerated. The role of pemetrexed as maintenance therapy after first-line therapy for advanced NSCLC is currently being evaluated into a phase III trial. The consistency of the results of these recent studies has identified a predictive effect of NSCLC non-squamous histology for pemetrexed. To date, pemetrexed is registered, at the dose of 500 mg/m(2) on day 1 of a 3-week schedule, in combination with cisplatin, for first-line therapy and, as single-agent, for second-line treatment of patients with non-squamous NSCLC.This review shows the latest and indicates the future developments of pemetrexed in the treatment of advanced NSCLC patients." @default.
- W2153397369 created "2016-06-24" @default.
- W2153397369 creator A5003664573 @default.
- W2153397369 creator A5029922900 @default.
- W2153397369 creator A5032078755 @default.
- W2153397369 creator A5045384053 @default.
- W2153397369 creator A5065057377 @default.
- W2153397369 date "2009-11-01" @default.
- W2153397369 modified "2023-09-25" @default.
- W2153397369 title "Pemetrexed in the treatment of advanced non-squamous lung cancer" @default.
- W2153397369 cites W1910732341 @default.
- W2153397369 cites W1968032729 @default.
- W2153397369 cites W1976565907 @default.
- W2153397369 cites W1980269766 @default.
- W2153397369 cites W1985329793 @default.
- W2153397369 cites W1996141967 @default.
- W2153397369 cites W2000480786 @default.
- W2153397369 cites W2020830322 @default.
- W2153397369 cites W2037139573 @default.
- W2153397369 cites W2041768451 @default.
- W2153397369 cites W2043103956 @default.
- W2153397369 cites W2045381419 @default.
- W2153397369 cites W2053144322 @default.
- W2153397369 cites W2055141641 @default.
- W2153397369 cites W2063374291 @default.
- W2153397369 cites W2064131908 @default.
- W2153397369 cites W2069562617 @default.
- W2153397369 cites W2070034364 @default.
- W2153397369 cites W2099725888 @default.
- W2153397369 cites W2100785570 @default.
- W2153397369 cites W2101087680 @default.
- W2153397369 cites W2102627969 @default.
- W2153397369 cites W2105527005 @default.
- W2153397369 cites W2112550921 @default.
- W2153397369 cites W2114998251 @default.
- W2153397369 cites W2115658330 @default.
- W2153397369 cites W2125730874 @default.
- W2153397369 cites W2131664752 @default.
- W2153397369 cites W2134667653 @default.
- W2153397369 cites W2135009190 @default.
- W2153397369 cites W2138297714 @default.
- W2153397369 cites W2138837920 @default.
- W2153397369 cites W2139142789 @default.
- W2153397369 cites W2139939379 @default.
- W2153397369 cites W2142703207 @default.
- W2153397369 cites W2144660856 @default.
- W2153397369 cites W2145835533 @default.
- W2153397369 cites W2154708694 @default.
- W2153397369 cites W2161245591 @default.
- W2153397369 cites W2913381773 @default.
- W2153397369 doi "https://doi.org/10.1016/j.lungcan.2009.06.006" @default.
- W2153397369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19577816" @default.
- W2153397369 hasPublicationYear "2009" @default.
- W2153397369 type Work @default.
- W2153397369 sameAs 2153397369 @default.
- W2153397369 citedByCount "51" @default.
- W2153397369 countsByYear W21533973692012 @default.
- W2153397369 countsByYear W21533973692013 @default.
- W2153397369 countsByYear W21533973692014 @default.
- W2153397369 countsByYear W21533973692015 @default.
- W2153397369 countsByYear W21533973692016 @default.
- W2153397369 countsByYear W21533973692017 @default.
- W2153397369 countsByYear W21533973692018 @default.
- W2153397369 countsByYear W21533973692021 @default.
- W2153397369 countsByYear W21533973692022 @default.
- W2153397369 countsByYear W21533973692023 @default.
- W2153397369 crossrefType "journal-article" @default.
- W2153397369 hasAuthorship W2153397369A5003664573 @default.
- W2153397369 hasAuthorship W2153397369A5029922900 @default.
- W2153397369 hasAuthorship W2153397369A5032078755 @default.
- W2153397369 hasAuthorship W2153397369A5045384053 @default.
- W2153397369 hasAuthorship W2153397369A5065057377 @default.
- W2153397369 hasConcept C123321153 @default.
- W2153397369 hasConcept C126322002 @default.
- W2153397369 hasConcept C142724271 @default.
- W2153397369 hasConcept C143998085 @default.
- W2153397369 hasConcept C2776256026 @default.
- W2153397369 hasConcept C2776694085 @default.
- W2153397369 hasConcept C2777240266 @default.
- W2153397369 hasConcept C2777407522 @default.
- W2153397369 hasConcept C2778239845 @default.
- W2153397369 hasConcept C2780258809 @default.
- W2153397369 hasConcept C2780456651 @default.
- W2153397369 hasConcept C2781413609 @default.
- W2153397369 hasConcept C71924100 @default.
- W2153397369 hasConceptScore W2153397369C123321153 @default.
- W2153397369 hasConceptScore W2153397369C126322002 @default.
- W2153397369 hasConceptScore W2153397369C142724271 @default.
- W2153397369 hasConceptScore W2153397369C143998085 @default.
- W2153397369 hasConceptScore W2153397369C2776256026 @default.
- W2153397369 hasConceptScore W2153397369C2776694085 @default.
- W2153397369 hasConceptScore W2153397369C2777240266 @default.
- W2153397369 hasConceptScore W2153397369C2777407522 @default.
- W2153397369 hasConceptScore W2153397369C2778239845 @default.
- W2153397369 hasConceptScore W2153397369C2780258809 @default.
- W2153397369 hasConceptScore W2153397369C2780456651 @default.
- W2153397369 hasConceptScore W2153397369C2781413609 @default.
- W2153397369 hasConceptScore W2153397369C71924100 @default.