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- W2153397625 abstract "Prospective time–trend analyses on shifting etiology and trends of drug resistance in enteric fever are scarce. Using published and unpublished datasets from Nepal, we performed a systematic review and meta-analysis to understand the trends in etiology and resistance to antimicrobials that have occurred since 1993. Thirty-two studies involving 21 067 Salmonella enterica serotype Typhi (ST) and S. enterica serotype Paratyphi A (SPA) isolates were included. There was an increasing trend in enteric fever caused by SPA during the last 2 decades (P < .01). We observed sharply increasing trends in resistance to nalidixic acid and ciprofloxacin for both ST and SPA. In contrast, multi-drug resistance (MDR), resistance to traditional first-line antibiotics such as chloramphenicol and co-trimoxazole have significantly decreased for both organisms. The resistance to ceftriaxone has remained low, suggesting it is likely to remain useful as a reserve antibiotic for treatment. Trends in decreasing resistance to traditional first-line antibiotics and decreasing MDR provide an opportunity to reconsider these first-line antimicrobials as therapeutic options." @default.
- W2153397625 created "2016-06-24" @default.
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- W2153397625 date "2013-08-28" @default.
- W2153397625 modified "2023-10-17" @default.
- W2153397625 title "Trends of Etiology and Drug Resistance in Enteric Fever in the Last Two Decades in Nepal: A Systematic Review and Meta-analysis" @default.
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- W2153397625 doi "https://doi.org/10.1093/cid/cit563" @default.
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