FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153399329> ?p ?o ?g. }

• W2153399329 endingPage "1559" @default.
• W2153399329 startingPage "1550" @default.
• W2153399329 abstract "Evidence has accumulated from observational studies that people eating more fruits and vegetables, which are rich in beta-carotene (a violet to yellow plant pigment that acts as an antioxidant and can be converted to vitamin A by enzymes in the intestinal wall and liver) and retinol (an alcohol chemical form of vitamin A), and people having higher serum beta-carotene concentrations had lower rates of lung cancer. The Beta-Carotene and Retinol Efficacy Trial (CARET) tested the combination of 30 mg beta-carotene and 25,000 IU retinyl palmitate (vitamin A) taken daily against placebo in 18314 men and women at high risk of developing lung cancer. The CARET intervention was stopped 21 months early because of clear evidence of no benefit and substantial evidence of possible harm; there were 28% more lung cancers and 17% more deaths in the active intervention group (active = the daily combination of 30 mg beta-carotene and 25,000 IU retinyl palmitate). Promptly after the January 18, 1996, announcement that the CARET active intervention had been stopped, we published preliminary findings from CARET regarding cancer, heart disease, and total mortality.We present for the first time results based on the pre-specified analytic method, details about risk factors for lung cancer, and analyses of subgroups and of factors that possibly influence response to the intervention.CARET was a randomized, double-blinded, placebo-controlled chemoprevention trial, initiated with a pilot phase and then expanded 10-fold at six study centers. Cigarette smoking history and status and alcohol intake were assessed through participant self-report. Serum was collected from the participants at base line and periodically after randomization and was analyzed for beta-carotene concentration. An Endpoints Review Committee evaluated endpoint reports, including pathologic review of tissue specimens. The primary analysis is a stratified logrank test for intervention arm differences in lung cancer incidence, with weighting linearly to hypothesized full effect at 24 months after randomization. Relative risks (RRs) were estimated by use of Cox regression models; tests were performed for quantitative and qualitative interactions between the intervention and smoking status or alcohol intake. O'Brien-Fleming boundaries were used for stopping criteria at interim analyses. Statistical significance was set at the .05 alpha value, and all P values were derived from two-sided statistical tests.According to CARET's pre-specified analysis, there was an RR of 1.36 (95% confidence interval [CI] = 1.07-1.73; P = .01) for weighted lung cancer incidence for the active intervention group compared with the placebo group, and RR = 1.59 (95% CI = 1.13-2.23; P = .01) for weighted lung cancer mortality. All subgroups, except former smokers, had a point estimate of RR of 1.10 or greater for lung cancer. There are suggestions of associations of the excess lung cancer incidence with the highest quartile of alcohol intake (RR = 1.99; 95% CI = 1.28-3.09; test for heterogeneity of RR among quartiles of alcohol intake has P = .01, unadjusted for multiple comparisons) and with large-cell histology (RR = 1.89; 95% CI = 1.09-3.26; test for heterogeneity among histologic categories has P = .35), but not with base-line serum beta-carotene concentrations.CARET participants receiving the combination of beta-carotene and vitamin A had no chemopreventive benefit and had excess lung cancer incidence and mortality. The results are highly consistent with those found for beta-carotene in the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study in 29133 male smokers in Finland." @default.
• W2153399329 created "2016-06-24" @default.
• W2153399329 creator A5000350877 @default.
• W2153399329 creator A5003137749 @default.
• W2153399329 creator A5008478119 @default.
• W2153399329 creator A5019461399 @default.
• W2153399329 creator A5025897021 @default.
• W2153399329 creator A5029117574 @default.
• W2153399329 creator A5034710587 @default.
• W2153399329 creator A5042070796 @default.
• W2153399329 creator A5044579053 @default.
• W2153399329 creator A5058566040 @default.
• W2153399329 creator A5060872059 @default.
• W2153399329 creator A5063912769 @default.
• W2153399329 creator A5065841051 @default.
• W2153399329 creator A5086505326 @default.
• W2153399329 date "1996-11-06" @default.
• W2153399329 modified "2023-10-11" @default.
• W2153399329 title "Risk Factors for Lung Cancer and for Intervention Effects in CARET, the Beta-Carotene and Retinol Efficacy Trial" @default.
• W2153399329 cites W1525444530 @default.
• W2153399329 cites W1536527355 @default.
• W2153399329 cites W1591607269 @default.
• W2153399329 cites W1747674411 @default.
• W2153399329 cites W1757073049 @default.
• W2153399329 cites W1965628098 @default.
• W2153399329 cites W1966368391 @default.
• W2153399329 cites W1975642650 @default.
• W2153399329 cites W1988985184 @default.
• W2153399329 cites W2023782645 @default.
• W2153399329 cites W2033243284 @default.
• W2153399329 cites W2033624890 @default.
• W2153399329 cites W2054131543 @default.
• W2153399329 cites W2059707463 @default.
• W2153399329 cites W2066137233 @default.
• W2153399329 cites W2067152228 @default.
• W2153399329 cites W2074673068 @default.
• W2153399329 cites W2095986115 @default.
• W2153399329 cites W2113170181 @default.
• W2153399329 cites W2134604571 @default.
• W2153399329 cites W2137823234 @default.
• W2153399329 cites W2152960401 @default.
• W2153399329 cites W2185786396 @default.
• W2153399329 cites W2186936502 @default.
• W2153399329 cites W2272528306 @default.
• W2153399329 cites W2278426151 @default.
• W2153399329 cites W2315403385 @default.
• W2153399329 cites W2397016644 @default.
• W2153399329 cites W2463226422 @default.
• W2153399329 cites W2796700885 @default.
• W2153399329 doi "https://doi.org/10.1093/jnci/88.21.1550" @default.
• W2153399329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8901853" @default.
• W2153399329 hasPublicationYear "1996" @default.
• W2153399329 type Work @default.
• W2153399329 sameAs 2153399329 @default.
• W2153399329 citedByCount "1146" @default.
• W2153399329 countsByYear W21533993292012 @default.
• W2153399329 countsByYear W21533993292013 @default.
• W2153399329 countsByYear W21533993292014 @default.
• W2153399329 countsByYear W21533993292015 @default.
• W2153399329 countsByYear W21533993292016 @default.
• W2153399329 countsByYear W21533993292017 @default.
• W2153399329 countsByYear W21533993292018 @default.
• W2153399329 countsByYear W21533993292019 @default.
• W2153399329 countsByYear W21533993292020 @default.
• W2153399329 countsByYear W21533993292021 @default.
• W2153399329 countsByYear W21533993292022 @default.
• W2153399329 countsByYear W21533993292023 @default.
• W2153399329 crossrefType "journal-article" @default.
• W2153399329 hasAuthorship W2153399329A5000350877 @default.
• W2153399329 hasAuthorship W2153399329A5003137749 @default.
• W2153399329 hasAuthorship W2153399329A5008478119 @default.
• W2153399329 hasAuthorship W2153399329A5019461399 @default.
• W2153399329 hasAuthorship W2153399329A5025897021 @default.
• W2153399329 hasAuthorship W2153399329A5029117574 @default.
• W2153399329 hasAuthorship W2153399329A5034710587 @default.
• W2153399329 hasAuthorship W2153399329A5042070796 @default.
• W2153399329 hasAuthorship W2153399329A5044579053 @default.
• W2153399329 hasAuthorship W2153399329A5058566040 @default.
• W2153399329 hasAuthorship W2153399329A5060872059 @default.
• W2153399329 hasAuthorship W2153399329A5063912769 @default.
• W2153399329 hasAuthorship W2153399329A5065841051 @default.
• W2153399329 hasAuthorship W2153399329A5086505326 @default.
• W2153399329 hasBestOaLocation W21533993291 @default.
• W2153399329 hasConcept C121608353 @default.
• W2153399329 hasConcept C126322002 @default.
• W2153399329 hasConcept C142724271 @default.
• W2153399329 hasConcept C204787440 @default.
• W2153399329 hasConcept C27081682 @default.
• W2153399329 hasConcept C2776256026 @default.
• W2153399329 hasConcept C2776940978 @default.
• W2153399329 hasConcept C2778859900 @default.
• W2153399329 hasConcept C2779573558 @default.
• W2153399329 hasConcept C2780234812 @default.
• W2153399329 hasConcept C42407357 @default.
• W2153399329 hasConcept C71924100 @default.
• W2153399329 hasConcept C90924648 @default.
• W2153399329 hasConceptScore W2153399329C121608353 @default.
• W2153399329 hasConceptScore W2153399329C126322002 @default.

• next