FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153403183> ?p ?o ?g. }

• W2153403183 abstract "Abstract Background Hemoglobin E/β-thalassemia is particularly common in Southeast Asia and has variable symptoms ranging from mild to severe anemia. Previous investigations demonstrated the remarkable symptoms of β-thalassemia in terms of the acceleration of apoptotic cell death. Ineffective erythropoiesis has been studied in human hematopoietic stem cells, however the distinct apoptotic mechanism was unclear. Methods The phosphoproteome of bone marrow HSCs/CD34 + cells from HbE/β-thalassemic patients was analyzed using IMAC phosphoprotein isolation followed by LC-MS/MS detection. Decyder MS software was used to quantitate differentially expressed proteins in 3 patients and 2 normal donors. The differentially expressed proteins from HSCs/CD34 + cells were compared with HbE/β-thalassemia and normal HSCs. Results A significant change in abundance of 229 phosphoproteins was demonstrated. Importantly, the analysis of the candidate proteins revealed a high abundance of proteins that are commonly found in apoptotic cells including cytochrome C, caspase 6 and apoptosis inducing factors. Moreover, in the HSCs patients a significant increase was observed in a specific type of phosphoserine/threonine binding protein, which is known to act as an important signal mediator for the regulation of cell survival and apoptosis in HbE/β-thalassemia. Conclusions Our study used a novel method to investigate proteins that influence a particular pathway in a given disease or physiological condition. Ultimately, phosphoproteome profiling in HbE/β-thalassemic stem cells is an effective method to further investigate the cell death mechanism of ineffective erythropoiesis in β-thalassemia. Our report provides a comprehensive phosphoproteome, an important resource for the study of ineffective erythropoiesis and developing therapies for HbE/β-thalassemia." @default.
• W2153403183 created "2016-06-24" @default.
• W2153403183 creator A5008855739 @default.
• W2153403183 creator A5016902105 @default.
• W2153403183 creator A5030758045 @default.
• W2153403183 creator A5033126677 @default.
• W2153403183 creator A5049179921 @default.
• W2153403183 creator A5062771813 @default.
• W2153403183 creator A5080483221 @default.
• W2153403183 date "2011-06-25" @default.
• W2153403183 modified "2023-10-06" @default.
• W2153403183 title "Phosphoproteomic analysis of apoptotic hematopoietic stem cells from hemoglobin E/β-thalassemia" @default.
• W2153403183 cites W1555869617 @default.
• W2153403183 cites W1745598831 @default.
• W2153403183 cites W1775749144 @default.
• W2153403183 cites W1964891662 @default.
• W2153403183 cites W1969690844 @default.
• W2153403183 cites W1971604648 @default.
• W2153403183 cites W1976417809 @default.
• W2153403183 cites W1978664503 @default.
• W2153403183 cites W1981593008 @default.
• W2153403183 cites W1981826617 @default.
• W2153403183 cites W1988041754 @default.
• W2153403183 cites W2005441809 @default.
• W2153403183 cites W2006403047 @default.
• W2153403183 cites W2007827117 @default.
• W2153403183 cites W2009966959 @default.
• W2153403183 cites W2011785467 @default.
• W2153403183 cites W2017052599 @default.
• W2153403183 cites W2017664937 @default.
• W2153403183 cites W2017882868 @default.
• W2153403183 cites W2021538852 @default.
• W2153403183 cites W2027429767 @default.
• W2153403183 cites W2030569892 @default.
• W2153403183 cites W2038163496 @default.
• W2153403183 cites W2039193673 @default.
• W2153403183 cites W2048168473 @default.
• W2153403183 cites W2056182246 @default.
• W2153403183 cites W2060839501 @default.
• W2153403183 cites W2072881292 @default.
• W2153403183 cites W2079688882 @default.
• W2153403183 cites W2079713481 @default.
• W2153403183 cites W2082804323 @default.
• W2153403183 cites W2085871472 @default.
• W2153403183 cites W2088442622 @default.
• W2153403183 cites W2090187361 @default.
• W2153403183 cites W2104569796 @default.
• W2153403183 cites W2106021203 @default.
• W2153403183 cites W2108197605 @default.
• W2153403183 cites W2109156347 @default.
• W2153403183 cites W2112132009 @default.
• W2153403183 cites W2120269793 @default.
• W2153403183 cites W2123868590 @default.
• W2153403183 cites W2129124842 @default.
• W2153403183 cites W2133232851 @default.
• W2153403183 cites W2133500918 @default.
• W2153403183 cites W2137035181 @default.
• W2153403183 cites W2162103775 @default.
• W2153403183 cites W2162173224 @default.
• W2153403183 cites W2162857699 @default.
• W2153403183 cites W2164322506 @default.
• W2153403183 cites W2165047972 @default.
• W2153403183 cites W2167932805 @default.
• W2153403183 cites W2306964352 @default.
• W2153403183 cites W2320101893 @default.
• W2153403183 cites W4234693960 @default.
• W2153403183 cites W4246480901 @default.
• W2153403183 doi "https://doi.org/10.1186/1479-5876-9-96" @default.
• W2153403183 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3142509" @default.
• W2153403183 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21702968" @default.
• W2153403183 hasPublicationYear "2011" @default.
• W2153403183 type Work @default.
• W2153403183 sameAs 2153403183 @default.
• W2153403183 citedByCount "15" @default.
• W2153403183 countsByYear W21534031832012 @default.
• W2153403183 countsByYear W21534031832013 @default.
• W2153403183 countsByYear W21534031832014 @default.
• W2153403183 countsByYear W21534031832015 @default.
• W2153403183 countsByYear W21534031832016 @default.
• W2153403183 countsByYear W21534031832017 @default.
• W2153403183 countsByYear W21534031832019 @default.
• W2153403183 countsByYear W21534031832020 @default.
• W2153403183 countsByYear W21534031832021 @default.
• W2153403183 countsByYear W21534031832022 @default.
• W2153403183 countsByYear W21534031832023 @default.
• W2153403183 crossrefType "journal-article" @default.
• W2153403183 hasAuthorship W2153403183A5008855739 @default.
• W2153403183 hasAuthorship W2153403183A5016902105 @default.
• W2153403183 hasAuthorship W2153403183A5030758045 @default.
• W2153403183 hasAuthorship W2153403183A5033126677 @default.
• W2153403183 hasAuthorship W2153403183A5049179921 @default.
• W2153403183 hasAuthorship W2153403183A5062771813 @default.
• W2153403183 hasAuthorship W2153403183A5080483221 @default.
• W2153403183 hasBestOaLocation W21534031831 @default.
• W2153403183 hasConcept C10205521 @default.
• W2153403183 hasConcept C109159458 @default.
• W2153403183 hasConcept C125996951 @default.
• W2153403183 hasConcept C126322002 @default.
• W2153403183 hasConcept C190283241 @default.
• W2153403183 hasConcept C203014093 @default.

• next