FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153470036> ?p ?o ?g. }

• W2153470036 endingPage "1721" @default.
• W2153470036 startingPage "1712" @default.
• W2153470036 abstract "Nitric oxide (NO), generated by inducible NO synthase (iNOS) in migrating macrophages, is increased in glomerulonephritis. This study investigates the effect of NO inhibition on rat nephrotoxic nephritis (NTN) to clarify the role of NO production in glomerular damage. NTN was induced in Sprague Dawley rats by an injection of an anti-glomerular basement membrane (GBM) antibody. Urinary nitrite excretion and nitrite release from kidney slices (5.47 +/- 1.19 versus 2.15 +/- 0.73 nmol/mg protein, NTN versus Control, P < 0.05) were increased in NTN on day 2. Glomerular macrophage infiltration and intercellular adhesion molecule (ICAM)-1 expression increased from day 2. iNOS expression was increased in interstitial macrophages. Glomerular endothelial cell NOS (ecNOS) expression evaluated by counting immunogold particles along GBM was suppressed (0.06 +/- 0.02 versus 0.35 +/- 0.04 gold/micron GBM, P < 0.0001). Glomerular damage developed progressively. NG-nitro-L-arginine methyl ester (L-NAME), which inhibits both iNOS and ecNOS and aminoguanidine (AG), a relatively selective inhibitor for iNOS, equally suppressed nitrite in urine and renal tissue. Glomerular ICAM-1 expression and macrophage infiltration were reduced by L-NAME, but not by AG. Expression of ecNOS was significantly increased by L-NAME (0.91 +/- 0.08, P < 0.0001 versus NTN), but slightly by AG (0.18 +/- 0.04). AG significantly and L-NAME slightly attenuated the glomerular damage at day 4. In conclusion, suppression of iNOS prevents glomerular damage in the early stage of NTN. Treatment by L-NAME reduces macrophage infiltration by suppression of ICAM-1 expression, which may be explained by an increase in ecNOS expression." @default.
• W2153470036 created "2016-06-24" @default.
• W2153470036 creator A5006782913 @default.
• W2153470036 creator A5037592709 @default.
• W2153470036 creator A5044921310 @default.
• W2153470036 creator A5050209643 @default.
• W2153470036 creator A5063909273 @default.
• W2153470036 creator A5064686486 @default.
• W2153470036 creator A5086410506 @default.
• W2153470036 creator A5087004159 @default.
• W2153470036 date "1997-11-01" @default.
• W2153470036 modified "2023-10-18" @default.
• W2153470036 title "Role of nitric oxide in rat nephrotoxic nephritis" @default.
• W2153470036 cites W1965294836 @default.
• W2153470036 cites W1965688452 @default.
• W2153470036 cites W1975896607 @default.
• W2153470036 cites W19792897 @default.
• W2153470036 cites W1992176634 @default.
• W2153470036 cites W1994571766 @default.
• W2153470036 cites W2004475073 @default.
• W2153470036 cites W2014007285 @default.
• W2153470036 cites W2032837160 @default.
• W2153470036 cites W2034349509 @default.
• W2153470036 cites W2038464928 @default.
• W2153470036 cites W2041075406 @default.
• W2153470036 cites W2045846314 @default.
• W2153470036 cites W2054345018 @default.
• W2153470036 cites W2055855948 @default.
• W2153470036 cites W2059736568 @default.
• W2153470036 cites W2082085559 @default.
• W2153470036 cites W2094610390 @default.
• W2153470036 cites W2097571046 @default.
• W2153470036 cites W2131868847 @default.
• W2153470036 cites W2134785329 @default.
• W2153470036 cites W2149478838 @default.
• W2153470036 cites W2164101329 @default.
• W2153470036 cites W2209831038 @default.
• W2153470036 cites W2317196764 @default.
• W2153470036 cites W2319716687 @default.
• W2153470036 cites W2409863766 @default.
• W2153470036 cites W2412710802 @default.
• W2153470036 cites W2415332515 @default.
• W2153470036 cites W2472948405 @default.
• W2153470036 cites W2473010778 @default.
• W2153470036 doi "https://doi.org/10.1681/asn.v8111712" @default.
• W2153470036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9355074" @default.
• W2153470036 hasPublicationYear "1997" @default.
• W2153470036 type Work @default.
• W2153470036 sameAs 2153470036 @default.
• W2153470036 citedByCount "49" @default.
• W2153470036 countsByYear W21534700362012 @default.
• W2153470036 countsByYear W21534700362013 @default.
• W2153470036 countsByYear W21534700362019 @default.
• W2153470036 crossrefType "journal-article" @default.
• W2153470036 hasAuthorship W2153470036A5006782913 @default.
• W2153470036 hasAuthorship W2153470036A5037592709 @default.
• W2153470036 hasAuthorship W2153470036A5044921310 @default.
• W2153470036 hasAuthorship W2153470036A5050209643 @default.
• W2153470036 hasAuthorship W2153470036A5063909273 @default.
• W2153470036 hasAuthorship W2153470036A5064686486 @default.
• W2153470036 hasAuthorship W2153470036A5086410506 @default.
• W2153470036 hasAuthorship W2153470036A5087004159 @default.
• W2153470036 hasBestOaLocation W21534700361 @default.
• W2153470036 hasConcept C121332964 @default.
• W2153470036 hasConcept C126189478 @default.
• W2153470036 hasConcept C126322002 @default.
• W2153470036 hasConcept C134018914 @default.
• W2153470036 hasConcept C153400128 @default.
• W2153470036 hasConcept C185592680 @default.
• W2153470036 hasConcept C2776115139 @default.
• W2153470036 hasConcept C2777058396 @default.
• W2153470036 hasConcept C2777622882 @default.
• W2153470036 hasConcept C2780091579 @default.
• W2153470036 hasConcept C2780368995 @default.
• W2153470036 hasConcept C519581460 @default.
• W2153470036 hasConcept C71924100 @default.
• W2153470036 hasConcept C86803240 @default.
• W2153470036 hasConcept C97355855 @default.
• W2153470036 hasConceptScore W2153470036C121332964 @default.
• W2153470036 hasConceptScore W2153470036C126189478 @default.
• W2153470036 hasConceptScore W2153470036C126322002 @default.
• W2153470036 hasConceptScore W2153470036C134018914 @default.
• W2153470036 hasConceptScore W2153470036C153400128 @default.
• W2153470036 hasConceptScore W2153470036C185592680 @default.
• W2153470036 hasConceptScore W2153470036C2776115139 @default.
• W2153470036 hasConceptScore W2153470036C2777058396 @default.
• W2153470036 hasConceptScore W2153470036C2777622882 @default.
• W2153470036 hasConceptScore W2153470036C2780091579 @default.
• W2153470036 hasConceptScore W2153470036C2780368995 @default.
• W2153470036 hasConceptScore W2153470036C519581460 @default.
• W2153470036 hasConceptScore W2153470036C71924100 @default.
• W2153470036 hasConceptScore W2153470036C86803240 @default.
• W2153470036 hasConceptScore W2153470036C97355855 @default.
• W2153470036 hasIssue "11" @default.
• W2153470036 hasLocation W21534700361 @default.
• W2153470036 hasOpenAccess W2153470036 @default.
• W2153470036 hasPrimaryLocation W21534700361 @default.
• W2153470036 hasRelatedWork W1571349016 @default.

• next