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• W2153481866 abstract "To review the scientific literature evaluating the efficacy and tolerability of tiotropium bromide, a new bronchodilator indicated for treatment of chronic obstructive pulmonary disease (COPD).Articles were identified through searches of MEDLINE (1966-January 2005) using the key words tiotropium, BA 679 BR, chronic obstructive pulmonary disease, and anticholinergic agents. Additional citations were identified from bibliographies of publications cited.Experimental and observational studies of tiotropium bromide were selected. Trials of the efficacy of the drug in humans were the focus of the review.Tiotropium bromide is an effective bronchodilator for patients with COPD. It produces clinically important improvements in lung function, symptoms of dyspnea, quality of life, and exacerbation rates compared with placebo. In comparative studies, tiotropium does not appear to be more efficacious than salmeterol or ipratropium.Tiotropium is an effective inhaled anticholinergic agent that is recommended among preferred long-acting bronchodilators for the chronic management of moderate to very severe COPD. Although similar to ipratropium in efficacy and tolerability, it has the advantage of once-daily dosing." @default.
• W2153481866 created "2016-06-24" @default.
• W2153481866 creator A5004595424 @default.
• W2153481866 creator A5055319594 @default.
• W2153481866 date "2005-09-01" @default.
• W2153481866 modified "2023-10-18" @default.
• W2153481866 title "Tiotropium: A Bronchodilator for Chronic Obstructive Pulmonary Disease" @default.
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• W2153481866 doi "https://doi.org/10.1345/aph.1e469" @default.
• W2153481866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16030078" @default.
• W2153481866 hasPublicationYear "2005" @default.
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