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- W2153497514 abstract "Surface engineering of a hydrogel nanoparticle (NP) with the tumor-targeting ligand, F3 peptide, enhances both the NP's binding affinity for, and internalization by, nucleolin overexpressing tumor cells. Remarkably, the F3-functionalized NPs consistently exhibited significantly lower trafficking to the degradative lysosomes than the non-functionalized NPs, in the tumor cells, after internalization. This is attributed to the non-functionalized NPs, but not the F3-functionalized NPs, being co-internalized with Lysosome-associated Membrane Protein-1 (LAMP1) from the surface of the tumor cells. Furthermore, it is shown that the intracellular trafficking of the F3-functionalized NPs differs significantly from that of the molecular F3 peptides (untethered to NPs). This has important implications for designing effective, chemically-responsive, controlled-release and multifunctional nanodrugs for multi-drug-resistant cancers." @default.
- W2153497514 created "2016-06-24" @default.
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- W2153497514 date "2013-01-01" @default.
- W2153497514 modified "2023-10-02" @default.
- W2153497514 title "Modulation of hydrogel nanoparticle intracellular trafficking by multivalent surface engineering with tumor targeting peptide" @default.
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- W2153497514 doi "https://doi.org/10.1039/c3nr00908d" @default.
- W2153497514 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3823366" @default.
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- W2153497514 hasPublicationYear "2013" @default.
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