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- W2153540079 abstract "A characteristic balanced reciprocal chromosomal translocation [t(2;13)(q35;q14)] has been identified in more than 50% of alveolar rhabdomyosarcomas. As the first step in characterization of the genes involved in this translocation, we constructed somatic cell hybrids that retained either the derivative chromosome 2 or the derivative chromosome 13 without a normal chromosome 13 homologue. Ten linked DNA probes known to be located within bands 13q13-q14 were mapped relative to the breakpoint on chromosome 13, allowing localization of the breakpoint region between two loci separated by 5.5 cM. A long-range restriction map extending approximately 2,300 kb around these loci failed to provide evidence of rearrangement. Additionally, we confirmed that the FMS-like tyrosine kinase gene (FLT), previously localized to 13q12 by in situ hybridization, is located proximal to the breakpoint, and we demonstrated that FLT is not a target for disruption by this tumor-specific translocation." @default.
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- W2153540079 date "1992-04-01" @default.
- W2153540079 modified "2023-09-23" @default.
- W2153540079 title "Chromosomal sublocalization of the 2;13 translocation breakpoint in alveolar rhabdomyosarcoma" @default.
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- W2153540079 doi "https://doi.org/10.1002/gcc.2870040309" @default.
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