FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153552852> ?p ?o ?g. }

• W2153552852 endingPage "1829" @default.
• W2153552852 startingPage "1821" @default.
• W2153552852 abstract "Quinolone-resistant Neisseria gonorrhoeae (QRNG) arise from mutations in gyrA (intermediate resistance) or gyrA and parC (resistance). Here we tested the consequence of commonly isolated gyrA(91/95) and parC86 mutations on gonococcal fitness.Mutant gyrA(91/95) and parC86 alleles were introduced into wild-type gonococci or an isogenic mutant that is resistant to macrolides due to an mtrR(-79) mutation. Wild-type and mutant bacteria were compared for growth in vitro and in competitive murine infection.In vitro growth was reduced with increasing numbers of mutations. Interestingly, the gyrA(91/95) mutation conferred an in vivo fitness benefit to wild-type and mtrR(-79) mutant gonococci. The gyrA(91/95), parC86 mutant, in contrast, showed a slight fitness defect in vivo, and the gyrA(91/95), parC86, mtrR(-79) mutant was markedly less fit relative to the parent strains. A ciprofloxacin-resistant (Cip(R)) mutant was selected during infection with the gyrA(91/95), parC86, mtrR(-79) mutant in which the mtrR(-79) mutation was repaired and the gyrA(91) mutation was altered. This in vivo-selected mutant grew as well as the wild-type strain in vitro.gyrA(91/95) mutations may contribute to the spread of QRNG. Further acquisition of a parC86 mutation abrogates this fitness advantage; however, compensatory mutations can occur that restore in vivo fitness and maintain Cip(R)." @default.
• W2153552852 created "2016-06-24" @default.
• W2153552852 creator A5003735630 @default.
• W2153552852 creator A5004551370 @default.
• W2153552852 creator A5014657510 @default.
• W2153552852 creator A5018104424 @default.
• W2153552852 creator A5039264196 @default.
• W2153552852 creator A5050347067 @default.
• W2153552852 creator A5056932320 @default.
• W2153552852 creator A5088902909 @default.
• W2153552852 date "2012-04-05" @default.
• W2153552852 modified "2023-10-10" @default.
• W2153552852 title "Impact of Fluoroquinolone Resistance Mutations on Gonococcal Fitness and In Vivo Selection for Compensatory Mutations" @default.
• W2153552852 cites W1632099083 @default.
• W2153552852 cites W1970727566 @default.
• W2153552852 cites W1975300709 @default.
• W2153552852 cites W1977685479 @default.
• W2153552852 cites W1980588572 @default.
• W2153552852 cites W1981704703 @default.
• W2153552852 cites W1982392457 @default.
• W2153552852 cites W1990949770 @default.
• W2153552852 cites W1998640667 @default.
• W2153552852 cites W2002621027 @default.
• W2153552852 cites W2011253627 @default.
• W2153552852 cites W2043887558 @default.
• W2153552852 cites W2054233015 @default.
• W2153552852 cites W2055500210 @default.
• W2153552852 cites W2075476726 @default.
• W2153552852 cites W2082504556 @default.
• W2153552852 cites W2084917638 @default.
• W2153552852 cites W2093267272 @default.
• W2153552852 cites W2099529711 @default.
• W2153552852 cites W2100409641 @default.
• W2153552852 cites W2102975216 @default.
• W2153552852 cites W2110156862 @default.
• W2153552852 cites W2111012112 @default.
• W2153552852 cites W2112765446 @default.
• W2153552852 cites W2113556104 @default.
• W2153552852 cites W2122820326 @default.
• W2153552852 cites W2126481846 @default.
• W2153552852 cites W2141844502 @default.
• W2153552852 cites W2146799886 @default.
• W2153552852 cites W2147841773 @default.
• W2153552852 cites W2148171562 @default.
• W2153552852 cites W2149652213 @default.
• W2153552852 cites W2150442967 @default.
• W2153552852 cites W2153246922 @default.
• W2153552852 cites W2155599871 @default.
• W2153552852 cites W2160043086 @default.
• W2153552852 cites W2163912696 @default.
• W2153552852 cites W2168362662 @default.
• W2153552852 cites W2168604776 @default.
• W2153552852 cites W2170140074 @default.
• W2153552852 cites W2766112019 @default.
• W2153552852 doi "https://doi.org/10.1093/infdis/jis277" @default.
• W2153552852 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3415892" @default.
• W2153552852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22492860" @default.
• W2153552852 hasPublicationYear "2012" @default.
• W2153552852 type Work @default.
• W2153552852 sameAs 2153552852 @default.
• W2153552852 citedByCount "74" @default.
• W2153552852 countsByYear W21535528522012 @default.
• W2153552852 countsByYear W21535528522013 @default.
• W2153552852 countsByYear W21535528522014 @default.
• W2153552852 countsByYear W21535528522015 @default.
• W2153552852 countsByYear W21535528522016 @default.
• W2153552852 countsByYear W21535528522017 @default.
• W2153552852 countsByYear W21535528522018 @default.
• W2153552852 countsByYear W21535528522019 @default.
• W2153552852 countsByYear W21535528522020 @default.
• W2153552852 countsByYear W21535528522021 @default.
• W2153552852 countsByYear W21535528522022 @default.
• W2153552852 countsByYear W21535528522023 @default.
• W2153552852 crossrefType "journal-article" @default.
• W2153552852 hasAuthorship W2153552852A5003735630 @default.
• W2153552852 hasAuthorship W2153552852A5004551370 @default.
• W2153552852 hasAuthorship W2153552852A5014657510 @default.
• W2153552852 hasAuthorship W2153552852A5018104424 @default.
• W2153552852 hasAuthorship W2153552852A5039264196 @default.
• W2153552852 hasAuthorship W2153552852A5050347067 @default.
• W2153552852 hasAuthorship W2153552852A5056932320 @default.
• W2153552852 hasAuthorship W2153552852A5088902909 @default.
• W2153552852 hasBestOaLocation W21535528521 @default.
• W2153552852 hasConcept C104317684 @default.
• W2153552852 hasConcept C135763542 @default.
• W2153552852 hasConcept C143065580 @default.
• W2153552852 hasConcept C167125095 @default.
• W2153552852 hasConcept C207001950 @default.
• W2153552852 hasConcept C207583985 @default.
• W2153552852 hasConcept C2778087339 @default.
• W2153552852 hasConcept C2779166590 @default.
• W2153552852 hasConcept C43563269 @default.
• W2153552852 hasConcept C501734568 @default.
• W2153552852 hasConcept C54355233 @default.
• W2153552852 hasConcept C547475151 @default.
• W2153552852 hasConcept C86803240 @default.
• W2153552852 hasConcept C89423630 @default.
• W2153552852 hasConcept C98638677 @default.

• next