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- W2153571482 abstract "To investigate possible changes in cells and molecular mediators of airway inflammation following inhaled steroid treatment of stable COPD patients.Six-week open preliminary prospective study.A university respiratory disease clinic.: Stable COPD patients with mild disease.Six-week treatment with inhaled beclomethasone (1.5 mg die).The levels of interleukin (IL)-8, myeloperoxidase, eosinophilic cationic protein and tryptase, and cell numbers in bronchial lavage specimens were determined, and the symptom score, the endoscopic bronchitis index, and functional parameters were recorded.After treatment there were significant reductions in the lavage levels of IL-8 ([mean +/- SEM] 1,603.4 +/- 331.2 vs 1,119.2 +/- 265.3 pg/mL, respectively; p = 0. 01) and myeloperoxidase (1,614.5 +/- 682.3 vs 511.2 +/- 144.2 microg/L, respectively; p = 0.05), in cell numbers (250.6 +/- 27.7 vs 186.3 +/- 11.5 cells x 10(3)/mL, respectively; p = 0.04), neutrophil proportion (59.7 +/- 14.3% vs 31.5 +/- 10.1%; p = 0.01), symptom score (4.5 +/- 0.6 vs 1.4 +/- 0.5; p = 0.01), and bronchitis index (8.5 +/- 0.8 vs 5.5 +/- 0.7; p = 0.007).In stable patients with COPD, inhaled steroid treatment may induce changes on some cellular and molecular parameters of airway inflammation." @default.
- W2153571482 created "2016-06-24" @default.
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- W2153571482 date "2000-06-01" @default.
- W2153571482 modified "2023-09-27" @default.
- W2153571482 title "Inhaled Corticosteroids in Stable COPD Patients" @default.
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- W2153571482 doi "https://doi.org/10.1378/chest.117.6.1633" @default.
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