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- W2153577115 abstract "Human leukocyte antigen G (HLA-G) is a non-classic class I major histocompatibility complex (MHC) molecule characterized by low polymorphism in its coding region, a limited tissue distribution pattern in physiologic conditions, and expression through soluble isoforms and isoforms bound to surface membranes through alternative splicing. HLA-G is fairly known since it is involved in induction and maintenance of tolerance between the maternal immunologic system and the semi-allogeneic fetus at the level of the fetal-placental interface. Besides, several studies have indicated a wider immunoregulatory role of this molecule. In this context, the expression of HLA-G in inflammatory and rheumatologic diseases is a relatively recent research area. The first studies described the expression of HLA-G in several inflammatory myopathies, atopic dermatitis, and cutaneous psoriasis. Based on the findings that HLA-G could divert T helper responses to the Th2 type, it was hypothesized that HLA-G would be a protective molecule in inflammatory responses. In this article, we review the potential roles of the HLA-G molecule in the immune system and in several rheumatologic diseases, such as systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, and others." @default.
- W2153577115 created "2016-06-24" @default.
- W2153577115 creator A5015292787 @default.
- W2153577115 creator A5032935573 @default.
- W2153577115 creator A5060617894 @default.
- W2153577115 creator A5082221558 @default.
- W2153577115 date "2012-02-01" @default.
- W2153577115 modified "2023-10-03" @default.
- W2153577115 title "O papel do gene e da molécula HLA-G na expressão clínica das doenças reumatológicas" @default.
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- W2153577115 doi "https://doi.org/10.1590/s0482-50042012000100009" @default.
- W2153577115 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22286648" @default.
- W2153577115 hasPublicationYear "2012" @default.
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