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• W2153578890 abstract "High-grade gliomas are aggressive and uniformly fatal tumors, composed of a heterogeneous population of cells that include many with stem-cell-like properties. The acquisition of stem-like traits might contribute to glioma initiation, growth, and recurrence. Here we investigated the role of the transcription factor myeloid Elf-1 like factor (MEF, also known as ELF4) in gliomas. We found that MEF is highly expressed in both human and mouse glioblastomas and its absence impairs gliomagenesis in a PDGF-driven glioma mouse model. We show that modulation of MEF levels in both mouse neural stem cells and human glioblastoma cells has a significant impact on neurosphere formation. Moreover, we identify Sox2 as a direct downstream target of MEF. Taken together, our studies implicate MEF as a previously unrecognized gatekeeper gene in gliomagenesis that promotes stem cell characteristics through Sox2 activation." @default.
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• W2153578890 date "2012-12-01" @default.
• W2153578890 modified "2023-09-30" @default.
• W2153578890 title "MEF Promotes Stemness in the Pathogenesis of Gliomas" @default.
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• W2153578890 doi "https://doi.org/10.1016/j.stem.2012.09.012" @default.
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