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• W2153620104 abstract "The expression levels of the Wilms' tumor gene WT1 were examined in 36 cases of various types of human bone and soft-tissue sarcomas using quantitative real-time reverse transcription-poly-merase chain reaction (RT-PCR). They included 12 malignant fibrous histiocytomas (MFH), 3 malignant peripheral nerve sheath tumors (MPNST), 6 synovial sarcomas (SyS), 4 myxoid liposarco-mas (MyLS), one angiosarcoma (ACS), one clear cell sarcoma (CCS), and 9 osteosarcomas (OS). Eleven (92%) of 12 MFH, 2 (67%) of 3 MPNST, all (100%) of 6 SyS, 2 (50%) of 4 MyLS, one ACS, one CCS, and 5 (56%) of 9 OS cases overexpressed WT1 in the range of 1.4×10-3-3.9×10-1 levels (WT1 expression level in K562 leukemic cells was defined as 1.0). Thus, 28 (78%) out of 36 various types of human bone and soft-tissue sarcomas overexpressed the WT1 gene. Immunohistochemical analysis showed positive staining for WT1 protein in all of 4 cases (one case each of MFH, MyLS, ACS and OS) with WT1 gene Overexpression detected by RT-PCR analysis, demonstrating clearly that WT1 was expressed at the protein level in various types of human bone and soft-tissue sarcomas. The direct sequencing analysis of the WT1 genomic DNA showed no mutations in any of 10 exons of the WT1 gene in 8 different sarcoma samples (3 MFH, one SyS, one MyLS, one ACS, and 2 OS). The present study demonstrates that various types of human bone and soft-tissue sarcomas frequently overexpress the wild-type WT1 gene, suggesting an important role of the wild-type WT1 gene in tumorigenesis of various types of human bone and soft-tissue sarcomas. (Cancer Sci 2003; 94: 271–276)" @default.
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• W2153620104 date "2003-03-01" @default.
• W2153620104 modified "2023-10-18" @default.
• W2153620104 title "Overexpression of the Wilms' tumor gene WT1 in human bone and soft-tissue sarcomas" @default.
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• W2153620104 doi "https://doi.org/10.1111/j.1349-7006.2003.tb01432.x" @default.
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