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- W2153641920 endingPage "5608" @default.
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- W2153641920 abstract "Genes 4 and 5 of mouse hepatitis virus (MHV) are known to encode nonstructural proteins ns4, ns5a, and ns5b, whose function is unknown. In this study, we demonstrated that one of the MHV strains, MHV-S, did not synthesize mRNA 4 and made a smaller mRNA 5. Sequence analysis showed that the transcription initiation site for gene 4 of MHV-S was mutated from the consensus UCUAAAC to UUUAAAC, consistent with the idea that mutations in this region abolish mRNA synthesis. Furthermore, within gene 5 there were deletions totaling 307 nucleotides which deleted almost all of open reading frame 5a, but preserved open reading frame 5b of gene 5. Comparison of the growth of MHV-S with other MHV strains in DBT cells revealed no significant growth defect in MHV-S. These results suggest that ns4 and ns5a are not essential for viral replication in tissue culture cells, and thus join gene 2 and the hemagglutinin-esterase (HE) gene as nonessential viral genes in MHV." @default.
- W2153641920 created "2016-06-24" @default.
- W2153641920 creator A5065671943 @default.
- W2153641920 creator A5076763316 @default.
- W2153641920 date "1991-10-01" @default.
- W2153641920 modified "2023-10-01" @default.
- W2153641920 title "Mouse hepatitis virus S RNA sequence reveals that nonstructural proteins ns4 and ns5a are not essential for murine coronavirus replication" @default.
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- W2153641920 doi "https://doi.org/10.1128/jvi.65.10.5605-5608.1991" @default.
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