Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153644568> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2153644568 endingPage "443" @default.
- W2153644568 startingPage "439" @default.
- W2153644568 abstract "Bothrops erythromelas is responsible for many snake bites in northeastern Brazil. In the present study we determined the in vivo distribution of the venom following its subcutaneous injection into mice. B. erythromelas venom and albumin were labeled individually with 131I by the chloramine T method, and separated in a Sephacryl® S-200 column. The efficiency of labeling was 68%. Male Swiss mice (40-45 g), which had been provided with drinking water containing 0.05% KI over a period of 10 days prior to the experiment, were inoculated dorsally (sc) with 0.3 ml (2.35 x 105 cpm/mouse) of 131I-venom (N = 42), 131I-albumin or 131I (controls, N = 28 each). Thirty minutes and 1, 3, 6, 12, 18 and 24 h after inoculation, the animals were perfused with 0.85% NaCl and skin and various organs were collected in order to determine radioactivity content. There was a high rate of venom absorption in the skin (51%) within the first 30 min compared to albumin (20.1%) and free iodine (8.2%). Up to the third hour after injection there was a tendency for venom and albumin to concentrate in the stomach (3rd h), small intestine (3rd h) and large intestine (6th h). Both control groups had more radioactivity in the digestive tract, especially in the stomach, but these levels decreased essentially to baseline by 12-18 h postinjection. In the kidneys, the distribution profiles of venom, albumin and iodine were similar. Counts at 30 min postinjection were low in all three groups (1.37, 1.86 and 0.77, respectively), and diminished to essentially 0% by 12-18 h. Albumin tended to concentrate in muscle until the 3rd h postinjection (1.98%). There was a low binding of labeled venom in the liver (<0.54%), thyroid (<0.11%) and lungs (<0.08%), and no iodinated venom was detected in brain, heart, diaphragm, spleen or bladder. The low venom binding observed in most internal organs, comparable to that of albumin, suggests that B. erythromelas venom does not specifically target most internal organs. That is, the systemic effects of envenomation are mainly due to an indirect action" @default.
- W2153644568 created "2016-06-24" @default.
- W2153644568 creator A5008491558 @default.
- W2153644568 creator A5021060641 @default.
- W2153644568 creator A5032712794 @default.
- W2153644568 creator A5059009443 @default.
- W2153644568 creator A5068518333 @default.
- W2153644568 creator A5069005215 @default.
- W2153644568 creator A5086871510 @default.
- W2153644568 date "1998-03-01" @default.
- W2153644568 modified "2023-09-25" @default.
- W2153644568 title "Distribution of 131I-labeled Bothrops erythromelas venom in mice" @default.
- W2153644568 cites W1965936099 @default.
- W2153644568 cites W2033785962 @default.
- W2153644568 cites W2056751071 @default.
- W2153644568 cites W2069598654 @default.
- W2153644568 cites W2073561567 @default.
- W2153644568 cites W2074417628 @default.
- W2153644568 cites W2078990860 @default.
- W2153644568 cites W2396780378 @default.
- W2153644568 cites W2417018120 @default.
- W2153644568 doi "https://doi.org/10.1590/s0100-879x1998000300017" @default.
- W2153644568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9698795" @default.
- W2153644568 hasPublicationYear "1998" @default.
- W2153644568 type Work @default.
- W2153644568 sameAs 2153644568 @default.
- W2153644568 citedByCount "10" @default.
- W2153644568 countsByYear W21536445682012 @default.
- W2153644568 countsByYear W21536445682015 @default.
- W2153644568 countsByYear W21536445682016 @default.
- W2153644568 crossrefType "journal-article" @default.
- W2153644568 hasAuthorship W2153644568A5008491558 @default.
- W2153644568 hasAuthorship W2153644568A5021060641 @default.
- W2153644568 hasAuthorship W2153644568A5032712794 @default.
- W2153644568 hasAuthorship W2153644568A5059009443 @default.
- W2153644568 hasAuthorship W2153644568A5068518333 @default.
- W2153644568 hasAuthorship W2153644568A5069005215 @default.
- W2153644568 hasAuthorship W2153644568A5086871510 @default.
- W2153644568 hasBestOaLocation W21536445681 @default.
- W2153644568 hasConcept C126322002 @default.
- W2153644568 hasConcept C150903083 @default.
- W2153644568 hasConcept C165616093 @default.
- W2153644568 hasConcept C178790620 @default.
- W2153644568 hasConcept C185592680 @default.
- W2153644568 hasConcept C207001950 @default.
- W2153644568 hasConcept C2776125364 @default.
- W2153644568 hasConcept C2777367657 @default.
- W2153644568 hasConcept C2779422922 @default.
- W2153644568 hasConcept C2779448229 @default.
- W2153644568 hasConcept C2780512811 @default.
- W2153644568 hasConcept C539932907 @default.
- W2153644568 hasConcept C55493867 @default.
- W2153644568 hasConcept C71924100 @default.
- W2153644568 hasConcept C86803240 @default.
- W2153644568 hasConceptScore W2153644568C126322002 @default.
- W2153644568 hasConceptScore W2153644568C150903083 @default.
- W2153644568 hasConceptScore W2153644568C165616093 @default.
- W2153644568 hasConceptScore W2153644568C178790620 @default.
- W2153644568 hasConceptScore W2153644568C185592680 @default.
- W2153644568 hasConceptScore W2153644568C207001950 @default.
- W2153644568 hasConceptScore W2153644568C2776125364 @default.
- W2153644568 hasConceptScore W2153644568C2777367657 @default.
- W2153644568 hasConceptScore W2153644568C2779422922 @default.
- W2153644568 hasConceptScore W2153644568C2779448229 @default.
- W2153644568 hasConceptScore W2153644568C2780512811 @default.
- W2153644568 hasConceptScore W2153644568C539932907 @default.
- W2153644568 hasConceptScore W2153644568C55493867 @default.
- W2153644568 hasConceptScore W2153644568C71924100 @default.
- W2153644568 hasConceptScore W2153644568C86803240 @default.
- W2153644568 hasIssue "3" @default.
- W2153644568 hasLocation W21536445681 @default.
- W2153644568 hasLocation W21536445682 @default.
- W2153644568 hasLocation W21536445683 @default.
- W2153644568 hasLocation W21536445684 @default.
- W2153644568 hasOpenAccess W2153644568 @default.
- W2153644568 hasPrimaryLocation W21536445681 @default.
- W2153644568 hasRelatedWork W1998310021 @default.
- W2153644568 hasRelatedWork W2007171574 @default.
- W2153644568 hasRelatedWork W2026040137 @default.
- W2153644568 hasRelatedWork W2033045281 @default.
- W2153644568 hasRelatedWork W2079105333 @default.
- W2153644568 hasRelatedWork W2080855671 @default.
- W2153644568 hasRelatedWork W2279126568 @default.
- W2153644568 hasRelatedWork W2313013250 @default.
- W2153644568 hasRelatedWork W2403836425 @default.
- W2153644568 hasRelatedWork W2782389743 @default.
- W2153644568 hasVolume "31" @default.
- W2153644568 isParatext "false" @default.
- W2153644568 isRetracted "false" @default.
- W2153644568 magId "2153644568" @default.
- W2153644568 workType "article" @default.