FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153661532> ?p ?o ?g. }

• W2153661532 endingPage "1862" @default.
• W2153661532 startingPage "1856" @default.
• W2153661532 abstract "An acute increase in international normalized ratio (INR) to >3.0 in patients with chronic kidney disease (CKD) can associate with an unexplained acute increase in serum creatinine and accelerated progression of CKD. A subset of these patients have renal tubular obstruction by casts of red blood cells, presumably the dominant mechanism of the acute kidney injury described as warfarin-related nephropathy. Here, we developed an animal model of this acute kidney injury that is based on the 5/6-nephrectomy model to aid future investigation of the pathogenesis of this condition. We found that acute excessive anticoagulation with brodifacoum (“superwarfarin”) increased serum creatinine levels and hematuria in 5/6-nephrectomized rats but not in controls. In addition, morphologic findings in 5/6-nephrectomized rats included glomerular hemorrhage, occlusive red blood cell casts, and acute tubular injury, similar to the biopsy findings among affected patients. Furthermore, in the rat model, we observed an increase in apoptosis of glomerular endothelial cells. In summary, the 5/6-nephrectomy model combined with excessive anticoagulation may be a useful tool to study the pathogenesis of warfarin-related nephropathy." @default.
• W2153661532 created "2016-06-24" @default.
• W2153661532 creator A5009250620 @default.
• W2153661532 creator A5010304127 @default.
• W2153661532 creator A5012869295 @default.
• W2153661532 creator A5017133959 @default.
• W2153661532 creator A5033500089 @default.
• W2153661532 creator A5034404977 @default.
• W2153661532 creator A5042356850 @default.
• W2153661532 creator A5044705669 @default.
• W2153661532 creator A5064913957 @default.
• W2153661532 creator A5066504687 @default.
• W2153661532 creator A5077634371 @default.
• W2153661532 date "2011-10-01" @default.
• W2153661532 modified "2023-10-13" @default.
• W2153661532 title "Warfarin-Related Nephropathy Modeled by Nephron Reduction and Excessive Anticoagulation" @default.
• W2153661532 cites W1995791071 @default.
• W2153661532 cites W2009598063 @default.
• W2153661532 cites W2009966899 @default.
• W2153661532 cites W2018083916 @default.
• W2153661532 cites W2028161185 @default.
• W2153661532 cites W2038507245 @default.
• W2153661532 cites W2053154970 @default.
• W2153661532 cites W2083176768 @default.
• W2153661532 cites W2096405472 @default.
• W2153661532 cites W2133284524 @default.
• W2153661532 cites W2243393341 @default.
• W2153661532 doi "https://doi.org/10.1681/asn.2010101110" @default.
• W2153661532 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3279947" @default.
• W2153661532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21885669" @default.
• W2153661532 hasPublicationYear "2011" @default.
• W2153661532 type Work @default.
• W2153661532 sameAs 2153661532 @default.
• W2153661532 citedByCount "76" @default.
• W2153661532 countsByYear W21536615322012 @default.
• W2153661532 countsByYear W21536615322013 @default.
• W2153661532 countsByYear W21536615322014 @default.
• W2153661532 countsByYear W21536615322015 @default.
• W2153661532 countsByYear W21536615322016 @default.
• W2153661532 countsByYear W21536615322017 @default.
• W2153661532 countsByYear W21536615322018 @default.
• W2153661532 countsByYear W21536615322019 @default.
• W2153661532 countsByYear W21536615322020 @default.
• W2153661532 countsByYear W21536615322021 @default.
• W2153661532 countsByYear W21536615322022 @default.
• W2153661532 countsByYear W21536615322023 @default.
• W2153661532 crossrefType "journal-article" @default.
• W2153661532 hasAuthorship W2153661532A5009250620 @default.
• W2153661532 hasAuthorship W2153661532A5010304127 @default.
• W2153661532 hasAuthorship W2153661532A5012869295 @default.
• W2153661532 hasAuthorship W2153661532A5017133959 @default.
• W2153661532 hasAuthorship W2153661532A5033500089 @default.
• W2153661532 hasAuthorship W2153661532A5034404977 @default.
• W2153661532 hasAuthorship W2153661532A5042356850 @default.
• W2153661532 hasAuthorship W2153661532A5044705669 @default.
• W2153661532 hasAuthorship W2153661532A5064913957 @default.
• W2153661532 hasAuthorship W2153661532A5066504687 @default.
• W2153661532 hasAuthorship W2153661532A5077634371 @default.
• W2153661532 hasBestOaLocation W21536615321 @default.
• W2153661532 hasConcept C126322002 @default.
• W2153661532 hasConcept C126894567 @default.
• W2153661532 hasConcept C134018914 @default.
• W2153661532 hasConcept C159641895 @default.
• W2153661532 hasConcept C2776301958 @default.
• W2153661532 hasConcept C2777350860 @default.
• W2153661532 hasConcept C2778653478 @default.
• W2153661532 hasConcept C2779161974 @default.
• W2153661532 hasConcept C2780091579 @default.
• W2153661532 hasConcept C2780227381 @default.
• W2153661532 hasConcept C2780306776 @default.
• W2153661532 hasConcept C2780472472 @default.
• W2153661532 hasConcept C2780942790 @default.
• W2153661532 hasConcept C2781184683 @default.
• W2153661532 hasConcept C2781231759 @default.
• W2153661532 hasConcept C555293320 @default.
• W2153661532 hasConcept C71924100 @default.
• W2153661532 hasConcept C90924648 @default.
• W2153661532 hasConceptScore W2153661532C126322002 @default.
• W2153661532 hasConceptScore W2153661532C126894567 @default.
• W2153661532 hasConceptScore W2153661532C134018914 @default.
• W2153661532 hasConceptScore W2153661532C159641895 @default.
• W2153661532 hasConceptScore W2153661532C2776301958 @default.
• W2153661532 hasConceptScore W2153661532C2777350860 @default.
• W2153661532 hasConceptScore W2153661532C2778653478 @default.
• W2153661532 hasConceptScore W2153661532C2779161974 @default.
• W2153661532 hasConceptScore W2153661532C2780091579 @default.
• W2153661532 hasConceptScore W2153661532C2780227381 @default.
• W2153661532 hasConceptScore W2153661532C2780306776 @default.
• W2153661532 hasConceptScore W2153661532C2780472472 @default.
• W2153661532 hasConceptScore W2153661532C2780942790 @default.
• W2153661532 hasConceptScore W2153661532C2781184683 @default.
• W2153661532 hasConceptScore W2153661532C2781231759 @default.
• W2153661532 hasConceptScore W2153661532C555293320 @default.
• W2153661532 hasConceptScore W2153661532C71924100 @default.
• W2153661532 hasConceptScore W2153661532C90924648 @default.
• W2153661532 hasIssue "10" @default.
• W2153661532 hasLocation W21536615321 @default.
• W2153661532 hasLocation W21536615322 @default.

• next