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- W2153670376 endingPage "380" @default.
- W2153670376 startingPage "361" @default.
- W2153670376 abstract "Novel, culture-independent, molecular and metagenomic techniques have provided new insight into the complex interactions between the mammalian host and gut microbial species. It is increasingly evident that gut microbes may shape the host metabolic and immune network activity and ultimately influence the development of obesity and diabetes. We discuss the evidence connecting gut microflora to obesity and to type 1 and type 2 diabetes, and we present recent insights into potential mechanisms underlying this relationship: increased nutrient absorption from the diet, prolonged intestinal transit time, altered bile acid entero-hepatic cycle, increased cellular uptake of circulating triglycerides, enhanced de novo lipogenesis, reduced free fatty acid oxidation, altered tissue composition of biologically active polyunsaturated fatty acid, chronic low-grade inflammation triggered by the endotoxin toll-like receptor 4 axis, and altered intestinal barrier function." @default.
- W2153670376 created "2016-06-24" @default.
- W2153670376 creator A5022045437 @default.
- W2153670376 creator A5060083972 @default.
- W2153670376 creator A5061715771 @default.
- W2153670376 date "2011-02-18" @default.
- W2153670376 modified "2023-10-04" @default.
- W2153670376 title "Interactions Between Gut Microbiota and Host Metabolism Predisposing to Obesity and Diabetes" @default.
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