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• W2153674885 abstract "To determine the activity of cortisol in rats treated with exogenous adrenocorticotropic hormone (ACTH) and a resveratrol supplement.Forty-eight adult female rats and 16 male rats of the strain (Rattus norvegicus) that were three months old and with body weights ranging from 200 to 250 g for females and 300 to 350 g for males were used and kept in controlled environmental conditions: temperature of 20±2° C and light-dark cycles of 14 and 10 hours. They were fed a balanced diet and had free access to water. The rats were randomly divided into four groups: group 1 - was treated with 5 µg/kg of ACTH i.p. every twelve hours; group 2 - received the same treatment with ACTH plus a grape extract supplement (resveratrol) of 40 mg/kg; group 3 - only received grape extract (resveratrol); and group 4 - received a saline solution (0.9%) i.p. and oral, and served as controls. The experimental design was a 2×2 factorial with two levels ACTH and two polyphenol levels (grape extract).No significant differences were found in blood cortisol concentrations, by day and gender, or by treatment effects (0.75 µg/dL ± 0.11; p <0.001).Results suggest that chronic stress and consumption of resveratrol did not directly alter levels of plasmatic cortisol in either stressed or unstressed rats. It was concluded that the given dosage levels of ACTH possibly did not produce sufficient stimulation of the adrenal gland for these animals.Determinar la actividad de cortisol en ratas tratadas con hormona adrecorticotropa (ACTH) exógena y un suplemento de resveratrol.Se utilizaron 48 ratas hembras adultas y 16 machos de la cepa wistar (Rattus norvegicus) de tres meses de edad y con un peso corporal de 200-250 g y 300-350 g para hembras y machos, respectivamente, que permanecieron en condiciones ambientales controladas, temperatura 20±2° C de ciclos de luz-oscuridad de 14 y 10 horas, respectivamente. Se les proporcionó alimento balanceado con libre acceso a agua. Las ratas fueron divididas en cuatro grupos al azar así: grupo 1, fue tratado con 5 µg/kg de ACTH i.p. cada 12 horas; grupo 2, recibió el mismo tratamiento con ACTH además de una suplementación oral de 40 mg/kg de extracto deshidratado de uva (resveratrol); grupo 3, solo recibió extracto de uva y el grupo 4, recibió solución salina y sirvió como control y (0.9%) i.p. y oral. El diseño experimental fue en factorial 2×2, con dos niveles de ACTH y dos niveles de polifenol.No se encontraron diferencias significativas del cortisol sanguíneo, con respecto al día y sexo, entre los tratamientos (0.75 µg/dL ± 0.11; p <0.001).Los resultados sugieren que el estrés crónico y el consumo de resveratrol no alteran directamente los niveles plasmáticos de cortisol, en ratas estresadas y no estresadas. De la misma manera que, posiblemente la dosis utilizada de ACTH no produjo estimulación de la glándula suprarrenal en las ratas." @default.
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• W2153674885 date "2012-07-01" @default.
• W2153674885 modified "2023-09-23" @default.
• W2153674885 title "Plasma cortisol activity in rats under conditions of chronic stress supplemented with resveratrol." @default.
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