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- W2153677278 abstract "The role of the metabotropic glutamate receptor 5 (mGlu(5) receptor) in learning and memory and other behaviors are reviewed by examining the influence of selective antagonists and genetic knockout on performance. This receptor is involved in spatial learning, contextual fear conditioning, inhibitory avoidance, fear potentiated startle, and conditioned taste aversion. However, mGlu(5) receptor antagonists have proven to be ineffective in other learning tasks, such as the delayed-match-to-position test and a three-hole spatial learning task. Locomotion is often decreased by mGlu(5) receptor antagonists; and other behaviors such as social interaction and consummatory responses can also be affected. In mGlu(5) receptor knockout mice, performance in contextual fear conditioning and spatial water maze tasks is impaired. Although the available evidence is suggestive of an important contribution of mGlu(5) receptors to cognitive functions, further studies are needed, particularly those with in vivo evaluation of the role of mGlu(5) receptors in selective brain regions in different stages of memory formation." @default.
- W2153677278 created "2016-06-24" @default.
- W2153677278 creator A5040942172 @default.
- W2153677278 creator A5058529710 @default.
- W2153677278 creator A5061176156 @default.
- W2153677278 date "2010-08-01" @default.
- W2153677278 modified "2023-10-17" @default.
- W2153677278 title "Metabotropic glutamate receptor subtype 5 antagonism in learning and memory" @default.
- W2153677278 cites W1504788794 @default.
- W2153677278 cites W1557451274 @default.
- W2153677278 cites W1600525795 @default.
- W2153677278 cites W1950417202 @default.
- W2153677278 cites W1967356386 @default.
- W2153677278 cites W1968079956 @default.
- W2153677278 cites W1968840456 @default.
- W2153677278 cites W1970250058 @default.
- W2153677278 cites W1971162500 @default.
- W2153677278 cites W1972692021 @default.
- W2153677278 cites W1976996342 @default.
- W2153677278 cites W1978157729 @default.
- W2153677278 cites W1979594873 @default.
- W2153677278 cites W1980188005 @default.
- W2153677278 cites W1982908158 @default.
- W2153677278 cites W1986434830 @default.
- W2153677278 cites W1998656003 @default.
- W2153677278 cites W2002573865 @default.
- W2153677278 cites W2002674888 @default.
- W2153677278 cites W2004047410 @default.
- W2153677278 cites W2004854382 @default.
- W2153677278 cites W2005325329 @default.
- W2153677278 cites W2007051067 @default.
- W2153677278 cites W2008854028 @default.
- W2153677278 cites W2009041030 @default.
- W2153677278 cites W2010641582 @default.
- W2153677278 cites W2013432476 @default.
- W2153677278 cites W2014667545 @default.
- W2153677278 cites W2016293609 @default.
- W2153677278 cites W2018876606 @default.
- W2153677278 cites W2021087112 @default.
- W2153677278 cites W2022019721 @default.
- W2153677278 cites W2023731925 @default.
- W2153677278 cites W2031645017 @default.
- W2153677278 cites W2032685526 @default.
- W2153677278 cites W2036521491 @default.
- W2153677278 cites W2038156466 @default.
- W2153677278 cites W2038505488 @default.
- W2153677278 cites W2038826547 @default.
- W2153677278 cites W2039378247 @default.
- W2153677278 cites W2043473753 @default.
- W2153677278 cites W2043965124 @default.
- W2153677278 cites W2044598463 @default.
- W2153677278 cites W2046846134 @default.
- W2153677278 cites W2048080687 @default.
- W2153677278 cites W2051270342 @default.
- W2153677278 cites W2056016753 @default.
- W2153677278 cites W2056415796 @default.
- W2153677278 cites W2059956308 @default.
- W2153677278 cites W2061070984 @default.
- W2153677278 cites W2063623143 @default.
- W2153677278 cites W2065399310 @default.
- W2153677278 cites W2066829643 @default.
- W2153677278 cites W2068273333 @default.
- W2153677278 cites W2068572983 @default.
- W2153677278 cites W2072397199 @default.
- W2153677278 cites W2073047063 @default.
- W2153677278 cites W2074562127 @default.
- W2153677278 cites W2076697810 @default.
- W2153677278 cites W2080998606 @default.
- W2153677278 cites W2081108290 @default.
- W2153677278 cites W2081880248 @default.
- W2153677278 cites W2082142381 @default.
- W2153677278 cites W2085712319 @default.
- W2153677278 cites W2086257407 @default.
- W2153677278 cites W2093278874 @default.
- W2153677278 cites W2095256251 @default.
- W2153677278 cites W2103292884 @default.
- W2153677278 cites W2117465944 @default.
- W2153677278 cites W2124955976 @default.
- W2153677278 cites W2129134595 @default.
- W2153677278 cites W2131832591 @default.
- W2153677278 cites W2136749823 @default.
- W2153677278 cites W2137016574 @default.
- W2153677278 cites W2144235995 @default.
- W2153677278 cites W2146169076 @default.
- W2153677278 cites W2147753672 @default.
- W2153677278 cites W2155304312 @default.
- W2153677278 cites W2160239443 @default.
- W2153677278 cites W2161584310 @default.
- W2153677278 cites W2167116111 @default.
- W2153677278 cites W2168526882 @default.
- W2153677278 cites W2313176671 @default.
- W2153677278 cites W2318994705 @default.
- W2153677278 cites W2319201633 @default.
- W2153677278 cites W4232755968 @default.
- W2153677278 cites W4248835773 @default.
- W2153677278 doi "https://doi.org/10.1016/j.ejphar.2009.12.039" @default.
- W2153677278 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2892203" @default.
- W2153677278 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20363219" @default.