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- W2153705791 abstract "Knowledge of auto-immune chronic active hepatitis (AI-CAH) has developed since the 1940s. Using the analogy of the seven veils, the lifting of the first six could be represented by the finding of: hypergammaglobulinaemia; recognition of the clinical syndrome; the hepatic histopathology; the auto-immune serological markers; the response to corticosteroid/immuno-suppressive drugs; and the immunogenetic association with HLA B8; DR3. The lifting of the seventh veil, the ultimate understanding of AI-CAH, will require the following: consensus on criteria for specifying auto-immune hepatitis as an entity; identification of a liver-specific auto-antigen (or hepatocellular neo-antigen) as target of the immune attack; the nature of the immune effector process which causes hepatocellular destruction; the basis of the deranged immunoregulatory processes expressed as decreased immune suppressor activity; and processes by which ‘anti-immune’ drugs exert their ameliorative effects. Auto-immune hepatitis is not unique in the paucity of data on these questions." @default.
- W2153705791 created "2016-06-24" @default.
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- W2153705791 date "1988-04-01" @default.
- W2153705791 modified "2023-09-26" @default.
- W2153705791 title "Auto-immune hepatitis: Lifting the seventh veil" @default.
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- W2153705791 doi "https://doi.org/10.1111/j.1440-1746.1988.tb00233.x" @default.
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