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• W2153709028 abstract "Cytochrome P450BM-3 is a catalytically self-sufficient fatty acid hydroxylase containing one equivalent each of heme, FMN, and FAD. The heme and flavins reside in separate domains connected by a linker peptide. In an earlier study (Govindaraj S, Poulos T, 1995, Biochemistry 54:11221-11226), we found that the length but not the sequence of the linker connecting the heme and reductase domains is important for enzyme activity. In the present study, residues in the linker were replaced with Pro and Gly to probe the role that regular secondary structure plays in linker function. The rate of flavin-to-heme electron transfer and the fatty acid hydroxylase activities of the glycine and proline substitution mutants, including a six-proline substitution, did not change significantly relative to wild-type enzyme. These results indicate that the linker does not adopt any regular secondary structure essential for activity and that the length of the linker is the critical feature that controls flavin-to-heme electron transfer." @default.
• W2153709028 created "2016-06-24" @default.
• W2153709028 creator A5015794500 @default.
• W2153709028 creator A5022023739 @default.
• W2153709028 date "1996-07-01" @default.
• W2153709028 modified "2023-10-16" @default.
• W2153709028 title "Probing the structure of the linker connecting the reductase and heme domains of cytochrome P450BM-3 using site-directed mutagenesis" @default.
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• W2153709028 doi "https://doi.org/10.1002/pro.5560050717" @default.
• W2153709028 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2143464" @default.
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