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• W2153709373 startingPage "797" @default.
• W2153709373 abstract "The local cytokine environment and the presence of stimulatory signals determine whether circulating monocytes will finally acquire characteristics of dendritic cells (DCs) or macrophages. Because FcepsilonRI expressed on professional APCs, e.g., monocytes and DCs, has been suggested to play a key role in the pathophysiology of atopic diseases, we evaluated the effect of receptor ligation on the generation of monocyte-derived DCs (MoDCs). Aggregation of FcepsilonRI at the initiation of the IL-4-GM-CSF-driven differentiation resulted in the emergence of macrophage-like cells with a strong expression of the mannose receptor and a low level of CD1a and the DC-specific markers CD83 and the actin-bundling protein (p55). These cells sustained the ability to take up FITC-labeled Escherichia coli by phagocytosis and were significantly less efficient in stimulating purified allogeneic T cells. In addition, receptor ligation of FcepsilonRI at the beginning of the culture prevented the generation of MoDCs, mainly due to a dramatic increase in the IL-10 production. These results suggest that FcepsilonRI aggregation prevents the generation of CD1a(+) MoDCs and imply a novel pivotal function of this receptor in modulating the differentiation of monocytes." @default.
• W2153709373 created "2016-06-24" @default.
• W2153709373 creator A5021862730 @default.
• W2153709373 creator A5030364184 @default.
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• W2153709373 date "2001-07-15" @default.
• W2153709373 modified "2023-10-16" @default.
• W2153709373 title "Engagement of FcεRI on Human Monocytes Induces the Production of IL-10 and Prevents Their Differentiation in Dendritic Cells" @default.
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• W2153709373 doi "https://doi.org/10.4049/jimmunol.167.2.797" @default.
• W2153709373 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11441085" @default.
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