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- W2153734895 abstract "Pharmacological inhibitors that block amyloid precursor protein (APP) cleavage and the formation of senile plaques are under development for the treatment of familial Alzheimer's disease. Unfortunately, many inhibitors that block γ-secretase-mediated cleavage of APP also have immunosuppressive side effects. In addition to APP, numerous other proteins undergo γ-secretase-mediated cleavage. In order to develop safer inhibitors, it is necessary to determine which of the γ-secretase substrates contribute to the immunosuppressive effects. Because APP family members are widely expressed and are reported to influence calcium flux, transcription and apoptosis, they could be important for normal lymphocyte maturation. We find that APP and amyloid precursor-like protein 2 are expressed by stromal cells of thymus and lymph nodes, but not by lymphocytes. Although signals provided by thymic stromal cells are critical for normal T cell differentiation, lymphocyte development proceeds unperturbed in mice deficient for these APP family members." @default.
- W2153734895 created "2016-06-24" @default.
- W2153734895 creator A5019478791 @default.
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- W2153734895 date "2009-08-26" @default.
- W2153734895 modified "2023-09-27" @default.
- W2153734895 title "Amyloid precursor family proteins are expressed by thymic and lymph node stromal cells but are not required for lymphocyte development" @default.
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- W2153734895 doi "https://doi.org/10.1093/intimm/dxp083" @default.
- W2153734895 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2750246" @default.
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