FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153735574> ?p ?o ?g. }

• W2153735574 endingPage "64" @default.
• W2153735574 startingPage "55" @default.
• W2153735574 abstract "Minimally invasive diagnostic tests are needed in obstetrics to identify women at risk for complications during delivery. The apolipoproteins fluctuate in complexity and abundance in maternal plasma during pregnancy and could be incorporated into a blood test to evaluate this risk. The objective of this study was to examine the relative plasma concentrations of apolipoproteins and their biochemically modified subtypes (i.e. proteolytically processed, sialylated, cysteinylated, dimerized) over gestational time using a targeted mass spectrometry approach. Relative abundance of modified and unmodified apolipoproteins A-I, A-II, C-I, C-II, and C-III was determined by surface-enhanced laser desorption/ionization-time of flight-mass spectrometry in plasma prospectively collected from 11 gravidas with uncomplicated pregnancies at 4-5 gestational time points per patient. Apolipoproteins were readily identifiable by spectral pattern. Apo C-III(2) and Apo C-III(1) (doubly and singly sialylated Apo C-III subtypes) increased with gestational age (r(2)>0.8). Unmodified Apo A-II, Apo C-I, and Apo C-III(0) showed no correlation (r(2) = 0.01-0.1). Pro-Apo C-II did not increase significantly until third trimester (140 ± 13% of first trimester), but proteolytically cleaved, mature Apo C-II increased in late pregnancy (702 ± 130% of first trimester). Mature Apo C-II represented 6.7 ± 0.9% of total Apo C-II in early gestation and increased to 33 ± 4.5% in third trimester. A label-free, semiquantitative targeted proteomics approach was developed using LTQ-Orbitrap mass spectrometry to confirm the relative quantitative differences observed by surface-enhanced laser desorption/ionization-time of flight-mass spectrometry in Apo C-III and Apo C-II isoforms between first and third trimesters. Targeted apolipoprotein screening was applied to a cohort of term and preterm patients. Modified Apo A-II isoforms were significantly elevated in plasma from mothers who delivered prematurely relative to term controls (p = 0.02). These results support a role for targeted proteomics profiling approaches in monitoring healthy pregnancies and assessing risk of adverse obstetric outcomes." @default.
• W2153735574 created "2016-06-24" @default.
• W2153735574 creator A5010299693 @default.
• W2153735574 creator A5011533372 @default.
• W2153735574 creator A5027687952 @default.
• W2153735574 creator A5072687482 @default.
• W2153735574 creator A5077190152 @default.
• W2153735574 creator A5088955467 @default.
• W2153735574 creator A5090989884 @default.
• W2153735574 date "2013-01-01" @default.
• W2153735574 modified "2023-10-16" @default.
• W2153735574 title "Longitudinal Analysis of Maternal Plasma Apolipoproteins in Pregnancy: A Targeted Proteomics Approach" @default.
• W2153735574 cites W1573812669 @default.
• W2153735574 cites W1601892851 @default.
• W2153735574 cites W1617008218 @default.
• W2153735574 cites W1920171370 @default.
• W2153735574 cites W1930026518 @default.
• W2153735574 cites W1964605761 @default.
• W2153735574 cites W1971665541 @default.
• W2153735574 cites W1972829474 @default.
• W2153735574 cites W1978328397 @default.
• W2153735574 cites W1995897030 @default.
• W2153735574 cites W2008029664 @default.
• W2153735574 cites W2024153517 @default.
• W2153735574 cites W2024569103 @default.
• W2153735574 cites W2027515030 @default.
• W2153735574 cites W2032799874 @default.
• W2153735574 cites W2039611222 @default.
• W2153735574 cites W2039972256 @default.
• W2153735574 cites W2044336832 @default.
• W2153735574 cites W2062376206 @default.
• W2153735574 cites W2065697631 @default.
• W2153735574 cites W2067623853 @default.
• W2153735574 cites W2072196102 @default.
• W2153735574 cites W2072749722 @default.
• W2153735574 cites W2079815931 @default.
• W2153735574 cites W2085411110 @default.
• W2153735574 cites W2092418525 @default.
• W2153735574 cites W2097822207 @default.
• W2153735574 cites W2101683626 @default.
• W2153735574 cites W2102572519 @default.
• W2153735574 cites W2112909603 @default.
• W2153735574 cites W2124835835 @default.
• W2153735574 cites W2130084197 @default.
• W2153735574 cites W2145954750 @default.
• W2153735574 cites W2147381416 @default.
• W2153735574 cites W2147990253 @default.
• W2153735574 cites W2149562628 @default.
• W2153735574 cites W2158036267 @default.
• W2153735574 cites W2160083577 @default.
• W2153735574 cites W2162402529 @default.
• W2153735574 cites W2170960877 @default.
• W2153735574 cites W2185031068 @default.
• W2153735574 doi "https://doi.org/10.1074/mcp.m112.018192" @default.
• W2153735574 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3536909" @default.
• W2153735574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23059768" @default.
• W2153735574 hasPublicationYear "2013" @default.
• W2153735574 type Work @default.
• W2153735574 sameAs 2153735574 @default.
• W2153735574 citedByCount "27" @default.
• W2153735574 countsByYear W21537355742013 @default.
• W2153735574 countsByYear W21537355742014 @default.
• W2153735574 countsByYear W21537355742015 @default.
• W2153735574 countsByYear W21537355742016 @default.
• W2153735574 countsByYear W21537355742017 @default.
• W2153735574 countsByYear W21537355742018 @default.
• W2153735574 countsByYear W21537355742019 @default.
• W2153735574 countsByYear W21537355742020 @default.
• W2153735574 countsByYear W21537355742021 @default.
• W2153735574 countsByYear W21537355742022 @default.
• W2153735574 crossrefType "journal-article" @default.
• W2153735574 hasAuthorship W2153735574A5010299693 @default.
• W2153735574 hasAuthorship W2153735574A5011533372 @default.
• W2153735574 hasAuthorship W2153735574A5027687952 @default.
• W2153735574 hasAuthorship W2153735574A5072687482 @default.
• W2153735574 hasAuthorship W2153735574A5077190152 @default.
• W2153735574 hasAuthorship W2153735574A5088955467 @default.
• W2153735574 hasAuthorship W2153735574A5090989884 @default.
• W2153735574 hasBestOaLocation W21537355741 @default.
• W2153735574 hasConcept C126322002 @default.
• W2153735574 hasConcept C134018914 @default.
• W2153735574 hasConcept C162356407 @default.
• W2153735574 hasConcept C185592680 @default.
• W2153735574 hasConcept C2778163477 @default.
• W2153735574 hasConcept C2778376644 @default.
• W2153735574 hasConcept C2779234561 @default.
• W2153735574 hasConcept C43617362 @default.
• W2153735574 hasConcept C46973012 @default.
• W2153735574 hasConcept C54355233 @default.
• W2153735574 hasConcept C55493867 @default.
• W2153735574 hasConcept C62746215 @default.
• W2153735574 hasConcept C71924100 @default.
• W2153735574 hasConcept C86803240 @default.
• W2153735574 hasConceptScore W2153735574C126322002 @default.
• W2153735574 hasConceptScore W2153735574C134018914 @default.
• W2153735574 hasConceptScore W2153735574C162356407 @default.
• W2153735574 hasConceptScore W2153735574C185592680 @default.
• W2153735574 hasConceptScore W2153735574C2778163477 @default.

• next