FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2153742172> ?p ?o ?g. }

• W2153742172 endingPage "436" @default.
• W2153742172 startingPage "432" @default.
• W2153742172 abstract "To examine the possible involvement of insulin and glucose in regulation of pancreatic islet gene expression, hyperinsulinemic (insulin infusion 4.1 mU/kg per min) clamps were performed for 12 h in rats at two different levels of glycemia (either 3 or 8 mM). A control group received a saline infusion for 12 h. At the end of the 12-h study period, pancreatic RNA was extracted, proinsulin and amylin mRNAs were measured on total RNA, and glucokinase and glucose transporter (GLUT-2) mRNAs were measured on poly(A)+ RNA by dot blot analysis. In insulin-infused hypoglycemic rats, there was a 58% decrement in proinsulin mRNA (P less than 0.01) relative to levels in controls, with no change in amylin, glucokinase, or islet GLUT-2 mRNAs. In insulin-infused hyperglycemic rats, there was a comparable decrement (44%, P less than 0.01) in proinsulin mRNA and a smaller decrement in GLUT-2 mRNA (32%, P less than 0.05), with no change in amylin or glucokinase mRNAs relative to levels in control animals. These studies suggest that insulin has a negative feedback inhibitory effect on its own synthesis. The mechanism of inhibition is unknown. It could be a direct effect of insulin on its own transcription, or alternatively an indirect effect mediated by humoral or neural factors. Sustained hyperinsulinemia may lead to suppression of normal islet beta cells and may contribute to the ultimate hypoinsulinemia of noninsulin-dependent diabetes mellitus." @default.
• W2153742172 created "2016-06-24" @default.
• W2153742172 creator A5004335707 @default.
• W2153742172 creator A5014643889 @default.
• W2153742172 creator A5023938814 @default.
• W2153742172 creator A5084058345 @default.
• W2153742172 date "1992-02-01" @default.
• W2153742172 modified "2023-10-14" @default.
• W2153742172 title "Feedback inhibition of insulin gene expression by insulin." @default.
• W2153742172 cites W1479842759 @default.
• W2153742172 cites W1492057606 @default.
• W2153742172 cites W1494211618 @default.
• W2153742172 cites W1552247157 @default.
• W2153742172 cites W1581798949 @default.
• W2153742172 cites W1593001894 @default.
• W2153742172 cites W1605496649 @default.
• W2153742172 cites W1674418446 @default.
• W2153742172 cites W1946374064 @default.
• W2153742172 cites W1963743323 @default.
• W2153742172 cites W1964870991 @default.
• W2153742172 cites W1966150597 @default.
• W2153742172 cites W1966596779 @default.
• W2153742172 cites W1968565241 @default.
• W2153742172 cites W1970296714 @default.
• W2153742172 cites W1974894120 @default.
• W2153742172 cites W1977787382 @default.
• W2153742172 cites W1999495877 @default.
• W2153742172 cites W2000977514 @default.
• W2153742172 cites W2005642589 @default.
• W2153742172 cites W2013348837 @default.
• W2153742172 cites W2047135359 @default.
• W2153742172 cites W2048226041 @default.
• W2153742172 cites W2051877725 @default.
• W2153742172 cites W2059911808 @default.
• W2153742172 cites W2067346786 @default.
• W2153742172 cites W2090235818 @default.
• W2153742172 cites W2099545840 @default.
• W2153742172 cites W2116828634 @default.
• W2153742172 cites W2126229699 @default.
• W2153742172 cites W2129327954 @default.
• W2153742172 cites W2134812217 @default.
• W2153742172 cites W2146374150 @default.
• W2153742172 cites W2335958328 @default.
• W2153742172 doi "https://doi.org/10.1172/jci115602" @default.
• W2153742172 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/442869" @default.
• W2153742172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1737834" @default.
• W2153742172 hasPublicationYear "1992" @default.
• W2153742172 type Work @default.
• W2153742172 sameAs 2153742172 @default.
• W2153742172 citedByCount "48" @default.
• W2153742172 countsByYear W21537421722013 @default.
• W2153742172 countsByYear W21537421722014 @default.
• W2153742172 countsByYear W21537421722017 @default.
• W2153742172 countsByYear W21537421722018 @default.
• W2153742172 countsByYear W21537421722020 @default.
• W2153742172 countsByYear W21537421722023 @default.
• W2153742172 crossrefType "journal-article" @default.
• W2153742172 hasAuthorship W2153742172A5004335707 @default.
• W2153742172 hasAuthorship W2153742172A5014643889 @default.
• W2153742172 hasAuthorship W2153742172A5023938814 @default.
• W2153742172 hasAuthorship W2153742172A5084058345 @default.
• W2153742172 hasBestOaLocation W21537421721 @default.
• W2153742172 hasConcept C104317684 @default.
• W2153742172 hasConcept C105580179 @default.
• W2153742172 hasConcept C126322002 @default.
• W2153742172 hasConcept C134018914 @default.
• W2153742172 hasConcept C144855686 @default.
• W2153742172 hasConcept C150194340 @default.
• W2153742172 hasConcept C165220095 @default.
• W2153742172 hasConcept C185592680 @default.
• W2153742172 hasConcept C2777368190 @default.
• W2153742172 hasConcept C2777391703 @default.
• W2153742172 hasConcept C2779306644 @default.
• W2153742172 hasConcept C2780090379 @default.
• W2153742172 hasConcept C2780705028 @default.
• W2153742172 hasConcept C2780988686 @default.
• W2153742172 hasConcept C55493867 @default.
• W2153742172 hasConcept C71315377 @default.
• W2153742172 hasConcept C71924100 @default.
• W2153742172 hasConcept C86803240 @default.
• W2153742172 hasConcept C90061646 @default.
• W2153742172 hasConcept C98335778 @default.
• W2153742172 hasConceptScore W2153742172C104317684 @default.
• W2153742172 hasConceptScore W2153742172C105580179 @default.
• W2153742172 hasConceptScore W2153742172C126322002 @default.
• W2153742172 hasConceptScore W2153742172C134018914 @default.
• W2153742172 hasConceptScore W2153742172C144855686 @default.
• W2153742172 hasConceptScore W2153742172C150194340 @default.
• W2153742172 hasConceptScore W2153742172C165220095 @default.
• W2153742172 hasConceptScore W2153742172C185592680 @default.
• W2153742172 hasConceptScore W2153742172C2777368190 @default.
• W2153742172 hasConceptScore W2153742172C2777391703 @default.
• W2153742172 hasConceptScore W2153742172C2779306644 @default.
• W2153742172 hasConceptScore W2153742172C2780090379 @default.
• W2153742172 hasConceptScore W2153742172C2780705028 @default.
• W2153742172 hasConceptScore W2153742172C2780988686 @default.
• W2153742172 hasConceptScore W2153742172C55493867 @default.
• W2153742172 hasConceptScore W2153742172C71315377 @default.

• next