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- W2153742783 endingPage "537" @default.
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- W2153742783 abstract "The concept of epigenetics was pioneered in 1939 by the Edinburgh-based developmental biologist, Conrad H Waddington1 to encompass all aspects of embryological development, but today the term is more specifically applied to the study of hereditable change in the expression of genes without change in DNA sequences. In effect this amounts to a range of non-DNA-based mechanisms that control gene transcription.2 These epigenetic mechanisms may be influenced by environmental factors, and this has potential therapeutic implications. When epigenetic mechanisms are inherited, this has evolutionary significance.3,4 Genomic duplication, particularly the whole genomic duplications that result from hybridogenesis and polyploidy, also has evolutionary and medical implications. In this final review, we shall examine the evolutionary implications of epigenetics and genomic duplications for human evolution, and the potential such understanding offers to medicine." @default.
- W2153742783 created "2016-06-24" @default.
- W2153742783 creator A5010401535 @default.
- W2153742783 date "2009-12-01" @default.
- W2153742783 modified "2023-09-26" @default.
- W2153742783 title "An alternative approach to medical genetics based on modern evolutionary biology. Part 5: epigenetics and genomics" @default.
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- W2153742783 doi "https://doi.org/10.1258/jrsm.2009.090365" @default.
- W2153742783 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2789017" @default.
- W2153742783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19966129" @default.
- W2153742783 hasPublicationYear "2009" @default.
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