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• W2153743931 abstract "Angiostrongylus cantonensis can induce central nervous system (CNS) injury and cause human eosinophilic meningitis. The CNS has been found to have high expression of interleukin 33 (IL-33), which promotes the pathogenesis of T-helper 2 (Th2)–related disease. Given the predominantly type 2 response induced by A. cantonensis–infected mice and human, it is likely that IL-33 may play a role in aiding this process. We report here that IL-33 protein and ST2L messenger RNA (mRNA) transcripts in the brains were upregulated during A. cantonensis infection and that both splenocytes and brain mononuclear cells became IL-33 responsive and produced interleukin 5 and interleukin 13. Furthermore, administration of IL-33 to A. cantonensis–infected mice enhanced ST2L expression and cytokine production. Interestingly, brain IL-33 protein and ST2L mRNA levels were elevated 14–21 days after infection in BALB/c mice, compared with C57BL/6 mice. Thus, our data indicate that IL-33 produced in the brain may function as an inflammatory mediator in eosinophilic meningitis induced by A. cantonensis." @default.
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• W2153743931 date "2012-11-12" @default.
• W2153743931 modified "2023-09-23" @default.
• W2153743931 title "Interleukin 33 Mediates Type 2 Immunity and Inflammation in the Central Nervous System of Mice Infected With Angiostrongylus cantonensis" @default.
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• W2153743931 doi "https://doi.org/10.1093/infdis/jis682" @default.
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